2013
DOI: 10.1016/j.placenta.2012.12.006
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Abstract: Together, these results suggest that trophoblast cells are able to modulate monocyte activity, resulting in the control of T. gondii infection and subsequent maintenance of pregnancy.

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Cited by 51 publications
(77 citation statements)
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“…This was found in a previous study that demonstrated an impaired immune response against bacterial stimuli in human monocytes (THP-1) cultured with trophoblast supernatant, especially reduced IL6 levels, showing the ability of trophoblast cells to modulate the immune response in cells found in the maternal-fetal interface [56]. Also, our previous study showed that the supernatant of BeWo cells induced increased IL10 and IL6 production in THP-1 cells [18]. Therefore, although trophoblast cells are not considered cells with innate or adaptive immunity, they are potentially able to modulate the immune response in the maternal-fetal interface.…”
Section: Discussionsupporting
confidence: 73%
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“…This was found in a previous study that demonstrated an impaired immune response against bacterial stimuli in human monocytes (THP-1) cultured with trophoblast supernatant, especially reduced IL6 levels, showing the ability of trophoblast cells to modulate the immune response in cells found in the maternal-fetal interface [56]. Also, our previous study showed that the supernatant of BeWo cells induced increased IL10 and IL6 production in THP-1 cells [18]. Therefore, although trophoblast cells are not considered cells with innate or adaptive immunity, they are potentially able to modulate the immune response in the maternal-fetal interface.…”
Section: Discussionsupporting
confidence: 73%
“…Like TNFA, several studies have demonstrated the protective effect of IL6 against T. gondii infection [18,66,67], although not in trophoblast cells, and our study was the first to show this effect in a human trophoblast model. IL6 has important roles in the maternal-fetal interface that could explain its increased level in trophoblast cells [68][69][70].…”
Section: Discussionsupporting
confidence: 52%
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