Triterpenoids from Scorzonera veratrifolia Fenzl

Cetin, Betul; Şahin, Hasan; Sarı, Aynur

doi:10.5152/istanbuljpharm.2018.410411

Cited by 8 publications

(6 citation statements)

References 13 publications

(1 reference statement)

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“…Triterpenes of the genus Scorzonera should attract more attention since many of the members are providers of dietary triterpenes. There are several Scorzonera species that investigated for the content of triterpenes [35–38] . Current results of S. pygmaea are in accordance with these studies reporting compounds α‐amyrin, lupeol, lupeol acetate, taraxasterol, cycloartanol and cyclolanostanone.…”

Section: Resultssupporting

confidence: 82%

Terpenoid and Fatty Acid Profiling along with Anti‐Tyrosinase and Anti‐Urease Potentials of Scorzonera pygmaea Sibth. & Sm. an Endemic Plant of Turkey

Şahin

Boğa

Sarı

2022

Chemistry & Biodiversity

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Petroleum ether (PE), chloroform (CH), ethyl acetate (EA) and butanol (BU) fractions were obtained from ethanol extracts of the roots (SPR) and the above ground (SPH) parts of S. pygmaea. PE fractions were evaluated by GC/MS for profiling the terpenoids and the fatty acids of the plant. 29 compounds in total including saturated (major palmitic acid), unsaturated (major linoleic acid) fatty acids and triterpenes were tentatively determined. Short‐term extraction methods might be preferred to avoid esterification of fatty acids. Phytochemical profiles of SPR‐PE and SPH‐PE were found to be similar to each other and to other few Scorzonera species reported previously. These results will contribute to the chemotaxonomic studies about the genus which is considered taxonomically complex genus. Activity studies were carried out using kojic acid (87.10 % inhibition) standard for tyrosinase and thiourea (95.83 % inhibition) standard for urease. SPR‐CH was determined as the most potent fraction with 55.94 % and 55.10 % inhibition of tyrosinase and urease, respectively at the same concentration of the standards (200 microgram/mL). These moderate results might be considered encouraging for more detailed studies to determine the active compounds and to evaluate the plant's potential in pharmaceutical, food and cosmetic industries in terms of tyrosinase and urease inhibition.

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Section: Resultssupporting

confidence: 82%

Terpenoid and Fatty Acid Profiling along with Anti‐Tyrosinase and Anti‐Urease Potentials of Scorzonera pygmaea Sibth. & Sm. an Endemic Plant of Turkey

Şahin

Boğa

Sarı

2022

Chemistry & Biodiversity

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“…The samples used for the studies on S. veratrifolia were collected in eastern Turkey. The subaerial parts were separated from the aerial parts and extracted with methanol at room temperature [ 30 , 64 ].…”

Section: Phytochemical Composition Of Scorzonera Speciesmentioning

confidence: 99%

“…Subaerial parts of S. veratrifolia contain the following triterpenes: α-amyrin acetate, α-amyrinone, β-amyrin acetate, β-amyrinone, β-amyrin, ψ-taraxasterol, ψ-taraxasterol acetate, fern-7-en-3-one, germanicol, germanicol acetate, germanicone, lupenone, lupeol, lupeol acetate, taraxasterol, and taraxasterol acetate, as well as β-sitosterol [ 30 ]. The presence of chlorogenic acid, chlorogenic acid methyl ester, isochlorogenic acid A, cryptochlorogenic acid, 4,5-dicaffeoylquinic acid, together with scorzoveratrin and scorzoveratrozit has also been reported [ 64 ].…”

Section: Phytochemical Composition Of Scorzonera Speciesmentioning

confidence: 99%

“…Biennial plants or dwarf subshrubs are rare [ 19 ]. Plants within the genus Scorzonera are reported to contain flavonoids [ 12 , 13 , 22 , 23 , 24 ], phenolic acid derivatives [ 8 , 13 , 25 , 26 ], triterpenoids [ 18 , 23 , 27 , 28 , 29 , 30 , 31 ], sesquiterpenoids [ 14 , 17 , 20 , 32 , 33 , 34 ], dihydroisocoumarins [ 7 , 35 , 36 , 37 ], and other bioactive compounds. Scorzonera species have been commonly used as medicinal plants in European and Asian herbal therapy for ages.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Composition and Biological Activities of Scorzonera Species

Lendzion

Gornowicz

Bielawski

et al. 2021

IJMS

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The genus Scorzonera comprises nearly 200 species, naturally occurring in Europe, Asia, and northern parts of Africa. Plants belonging to the Scorzonera genus have been a significant part of folk medicine in Asia, especially China, Mongolia, and Turkey for centuries. Therefore, they have become the subject of research regarding their phytochemical composition and biological activity. The aim of this review is to present and assess the phytochemical composition, and bioactive potential of species within the genus Scorzonera. Studies have shown the presence of many bioactive compounds like triterpenoids, sesquiterpenoids, flavonoids, or caffeic acid and quinic acid derivatives in extracts obtained from aerial and subaerial parts of the plants. The antioxidant and cytotoxic properties have been evaluated, together with the mechanism of anti-inflammatory, analgesic, and hepatoprotective activity. Scorzonera species have also been investigated for their activity against several bacteria and fungi strains. Despite mild cytotoxicity against cancer cell lines in vitro, the bioactive properties in wound healing therapy and the treatment of microbial infections might, in perspective, be the starting point for the research on Scorzonera species as active agents in medical products designed for miscellaneous skin conditions.

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“…Among them, the most abundant peaks belonged to ß-amyrin, lupeol, 13,27-cycloursan-3-olacetate, two cholestane derivatives, taraxasterol, germanicol, and lupeyl acetate which were previously reported from different Scorzonera species. [28,[38][39][40] Particularly, taraxasteryl acetate, olean-12-en-11-one-3-acetyl, lupeol, and lupeyl acetate were reported from S. incisa collected from a different location, by HPLC-DAD. [28] However, all other compounds were reported for the first time from S. incisa.…”

Section: Terpenoids and Fatty Acids Profilingmentioning

confidence: 99%

A Comprehensive Study on a Medicinal and Edible Plant Scorzonera incisa DC., Discussing the Natural Limits of Phytochemical Profiling

Şahin,

Demir,

Boğa

et al. 2023

ChemistrySelect

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Leaves of Scorzonera incisa DC. (Asteraceae) are eaten raw against diabetes and headache. Evaluation of medicinal, edible plants using profiling methods has become a common phenomenon. Petroleum ether (PE), ethyl acetate (EA), and n‐butanol (BU) fractions were prepared from ethanol extract of the aerial parts of the plant. Isolation by HPLC and phenolic profiling by validated LC‐MS/MS method with 53 compounds were conducted on the EA fraction. GC‐MS method was used to profile the PE fraction. In‐vitro inhibitory activities of all fractions against α‐amylase, α‐glucosidase, AChE, BChE, tyrosinase and urease enzymes were measured. Isoorientin, vitexin, cynaroside and chlorogenic acid were isolated and characterized from the EA fraction as major compounds. LC‐MS/MS analysis quantified 36 compounds in the EA fraction. 20 compounds were tentatively determined in the PE fraction. Compounds with the same molecular and fragment ions, a low percentage of identified compounds, and very close polarities were revealed to be some limits of the nature for LC‐MS/MS profiling. Particularly, the presence and amount of substances other than the standard compounds used in the profiling methods and possible misdetections should not be neglected in evaluating medicinal plants and establishing a correlation between compounds and bioactivity.

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Triterpenoids from Scorzonera veratrifolia Fenzl

Cited by 8 publications

References 13 publications

Terpenoid and Fatty Acid Profiling along with Anti‐Tyrosinase and Anti‐Urease Potentials of Scorzonera pygmaea Sibth. & Sm. an Endemic Plant of Turkey

Terpenoid and Fatty Acid Profiling along with Anti‐Tyrosinase and Anti‐Urease Potentials of Scorzonera pygmaea Sibth. & Sm. an Endemic Plant of Turkey

Phytochemical Composition and Biological Activities of Scorzonera Species

A Comprehensive Study on a Medicinal and Edible Plant Scorzonera incisa DC., Discussing the Natural Limits of Phytochemical Profiling

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