Triterpene saponins with <i>α</i>-glucosidase inhibition and cytotoxic activity from the leaves of <i>Schefflera sessiliflora</i>

Phat, Nguyen Tan; Lê, Thạch Ngọc; Phan, Nhat Minh; Bui, Trong Dat; Tri, Dinh

doi:10.1080/10286020.2015.1121999

Cited by 25 publications

(5 citation statements)

References 16 publications

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“…The quinoa husk extracts showed a lower IC 50 value of 32.62 mg/mL compared to that of acarbose (64.71 mg/mL), suggesting a stronger inhibition on α-glucosidase (p < 0.05). Our finding is consistent with the previous reports of the strong effect of triterpenoid saponins and flavonoids in inhibiting the activity of α-glucosidase [50,51]. Moreover, studies also suggest the functions of key groups in the structure of flavonoids and triterpenoid saponins in their α-glucosidase inhibiting activity, such as the number and position of hydroxyl groups and the carbonyl group in flavonoids [52] and the position of sugar moieties in the aglycon in triterpenoid saponins [53].…”

Section: Identification Of Chemical Constituents In Quinoa Husk Extractssupporting

confidence: 92%

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Shi

et al. 2022

Foods

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The present study extracted total saponins from quinoa husks with pressurized hot water extraction and optimized the extraction conditions. The response surface methodology (RSM) with a Box–Behnken design (BBD) was employed to investigate the effects of extraction flow rate, extraction temperature and extraction time on the extraction yield of total saponins. A maximal yield of 23.06 mg/g was obtained at conditions of 2 mL/min, 210 °C and 50 min. The constituents of the extracts were analyzed by liquid chromatography–mass spectrometry (LC-MS). A total of twenty-three compounds were identified, including five flavonoids, seventeen triterpenoid saponins and a phenolic acid. Moreover, we performed an in vitro assay for the α-glucosidase activity and found a stronger inhibitory effect of the quinoa husk extracts than acarbose, suggesting its potential to be developed into functional products with hypoglycemic effect. Finally, our molecular docking analyses indicated triterpenoid saponins as the main bioactive components.

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Section: Identification Of Chemical Constituents In Quinoa Husk Extractssupporting

confidence: 92%

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Shi

et al. 2022

Foods

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“…Several triterpenoid saponins were isolated from Gypsophila oldhamiana roots and the results shows that all active compounds exhibited better α-GIA than acarbose with IC50s between 15.2 and 98.2 µM, whereas the IC50 of acarbose was 388.0 µM [114] . Furthermore, in 2015, a study by Nguyena et al revealed that triterpenoid saponins isolated from Schefflera sessiliflora leaves showed greater α-GIA (IC50 = 5.99 -76.58 µM) than acarbose (IC50 = 214.5 µM) [115] , and this may support our hypothesis of saponin content are compounds responsible for α-GIA from the precipitate extract.…”

Section: α-Glucosidase Inhibitory Activitysupporting

confidence: 80%

Bioactivity of Walnut: Investigating the Triterpenoid Saponin Extracts of Juglans regia Kernels for Antioxidant, Anti-diabetic, and Antimicrobial Properties

Elouafy¹,

Mortada²,

Yadini³

et al. 2023

Prog Micobes Mol Biol

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The increasing demand for plant-based medicines makes plant research attractive to find natural alternatives that can replace synthetic products or at least reduce their use. Saponins are a group of natural phytochemical compounds in most herbs, vegetables, and legumes. There are two different types of saponin compounds, which can be classified based on the nature of the aglycone bound to the oligosaccharide fragments, whether it is a steroid or triterpenoid. This paper is devoted to saponins with triterpenoid aglycone and aims to study the relationship between their content and several biological activities in different Juglans regia kernel extracts, including antioxidant, antimicrobial and antibacterial activities. Antioxidant activity was assessed against two free radicals: DPPH and ABTS. Oleanolic acid was used as a standard to quantify triterpenoid saponins, measured by the vanillin method, whereas Acarbose and Tetracycline were used as positive controls to evaluate the α-glucosidase inhibitory and antimicrobial activities, respectively, of walnut kernel extracts. Findings show that hydroalcoholic extract (EtOH 70%) has a considerable content of phenolic compounds, with 59.51 ± 0.26 mg GAE/g in total polyphenol contents, while the content of total flavonoids and condensed tannins were 3.14 ± 0.27 mg QE/g and 85.65 ± 0.37 mg CE/g of crude extract, respectively. In terms of antioxidant activity, the butanolic extract proved to be the most effective against DPPH with IC50 = 7.74 ± 1.49 µg/mL, while the precipitated extract showed the highest scavenging activity against the ABTS free radical with IC50 = 33.14 ± 2.96 µg/mL. In addition, butanolic and hydroalcoholic extracts of Juglans regia kernels showed an α-glucosidase inhibitory activity even more efficiently than synthetic drugs such as Acarbose, with IC50 values of 11.66 µg/mL and 16.17 µg/mL, respectively, versus 18.01 µg/mL in Acarbose. The evaluation of the antimicrobial activity against Bacillus subtilis, Escherichia coli and Klebsiella pneumonia strains revealed that some extracts could inhibit these bacteria. This study successfully assessed the bioactivities of the extracts, suggesting that the extracts of medicinal plants can demonstrate stronger bioactivity than pure synthetic compounds.

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“…Even though there are reports on terpenoid saponins as α-glucosidase and α-amylase inhibitors, − as far as we know, this is the first report of a lanosterol saponin with α-amylase inhibitory activity.…”

Section: Resultsmentioning

confidence: 85%

Identification of α-Amylase and α-Glucosidase Inhibitors and Ligularoside A, a New Triterpenoid Saponin from Passiflora ligularis Juss (Sweet Granadilla) Leaves, by a Nuclear Magnetic Resonance-Based Metabolomic Study

Daza

Macías

Forero

et al. 2021

J. Agric. Food Chem.

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The leaves of Passiflora ligularis Juss (known as sweet granadilla for its edible fruits) are a crop byproduct that is discarded. With the aim of contributing to give value-added products from these crop by-side products to farmers of Colombian Andes, we carried out a 1H-NMR-metabolomics analysis of polar extracts from leaves collected in three locations and stored in two conditions in order to identify glucosyl-hydrolase inhibitors. Variations in the metabolic profile and the bioactivity among samples were analyzed by orthogonal partial least square discriminant analysis. Thus, 1H-NMR signals related to polyphenolic compounds, saponins, and amino acids were correlated with higher inhibitory activities. Moreover, a targeted NMR and HPLC–MS/MS analysis allowed the identification of 14 polyphenolic compounds and the structural characterization of a new triterpenoid saponin, ligularoside A. The measurements of IC50 values for α-amylase and α-glycosidase inhibitors allowed the identification of quercetin-3-O-β-glucoside, kaempferol-3-O-β-glucoside, and ligularoside A as the most active compounds. These results suggest that P. ligularis leaves are a source of glucosyl-hydrolase inhibitors and lay the foundation for exploring additional applications.

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Triterpene saponins with α-glucosidase inhibition and cytotoxic activity from the leaves of Schefflera sessiliflora

Cited by 25 publications

References 16 publications

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Bioactivity of Walnut: Investigating the Triterpenoid Saponin Extracts of Juglans regia Kernels for Antioxidant, Anti-diabetic, and Antimicrobial Properties

Identification of α-Amylase and α-Glucosidase Inhibitors and Ligularoside A, a New Triterpenoid Saponin from Passiflora ligularis Juss (Sweet Granadilla) Leaves, by a Nuclear Magnetic Resonance-Based Metabolomic Study

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