Triple threat: adiposity, aging, atrial fibrillation

Anumonwo, Justus M.B.; Jalife, José; Goldstein, Daniel R.

doi:10.18632/aging.101318

Cited by 4 publications

(3 citation statements)

References 8 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic inflammation is associated with several age-related diseases such as atherosclerosis, Alzheimer’s disease, sarcopenia, and arthritis (42). The genesis of chronic inflammation with aging is unclear, but inflammation could be an underlying mechanism that connects aging to atrial myopathy and AF (43). Clinical studies have connected various circulating inflammatory mediators, including C-reactive protein (CRP), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and immune complement activation, with persistent AF (44).…”

Section: Atrial Myopathy and The Aging Heartmentioning

confidence: 99%

“…Epicardial fat is a major source of adipokines, inflammatory cytokines, and free fatty acids, which contributes to fibrotic remodeling within the atrial myocardium (45). Macrophages and neutrophils are key cellular mediators of inflammation that may contribute to AF by infiltrating the atria or epicardial fat (46), releasing reactive oxygen species (ROS), and producing inflammatory cytokines, chemokines, metalloproteinases, or myeloperoxidases (43). Inflammation is also critical for insulin resistance in experimental models of diet-induced obesity (47).…”

Section: Atrial Myopathy and The Aging Heartmentioning

confidence: 99%

See 1 more Smart Citation

Atrial Myopathy

Shen¹,

Arora²,

Jalife³

2019

JACC: Basic to Translational Science

Self Cite

View full text Add to dashboard Buy / Rent full text

HighlightsThe authors discuss the concept of atrial myopathy; its relationship to aging, electrophysiological remodeling, and autonomic remodeling; the interplay between atrial myopathy, AF, and stroke; and suggest how to identify patients with atrial myopathy and how to incorporate atrial myopathy into decisions about anticoagulation.Atrial myopathy seen in animal models of AF and in patients with AF is the result of a combination of factors that lead to electrical and structural remodeling in the atrium. Although AF may lead to the initiation and/or progression of this myopathy, the presence of AF is by no means essential to the development or the maintenance of the atrial myopathic state.Methods to identify atrial myopathy include atrial electrograms, tissue biopsy, cardiac imaging, and certain serum biomarkers. A promising modality is 4-dimensional flow cardiac magnetic resonance. The concept of atrial myopathy may help guide oral anticoagulant therapy in selected groups of patients with AF, particularly those with low to intermediate risk of strokes and those who have undergone successful AF ablation. This review highlights the need for prospective randomized trials to test these hypotheses.

show abstract

Section: Atrial Myopathy and The Aging Heartmentioning

confidence: 99%

Section: Atrial Myopathy and The Aging Heartmentioning

confidence: 99%

Atrial Myopathy

Shen¹,

Arora²,

Jalife³

2019

JACC: Basic to Translational Science

Self Cite

View full text Add to dashboard Buy / Rent full text

show abstract

“…Acute inflammation is a major risk factor for PAC, such as that occurring in the postoperative period ( Jidéus et al, 2006 ; Dobrev et al, 2019 ). Chronic inflammation involving the enhancement of oxidative stress also seems to be involved in PAC physiopathology ( Anumonwo et al, 2017 ; Shen et al, 2019 ).…”

Section: Physiopathology and Epidemiology Of Nonsustained Atrial Arrh...mentioning

confidence: 99%

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

Guichard

Guasch²,

Roche³

et al. 2022

Front. Physiol.

View full text Add to dashboard Buy / Rent full text

An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications.

show abstract

Triple threat: adiposity, aging, atrial fibrillation

Cited by 4 publications

References 8 publications

Atrial Myopathy

Atrial Myopathy

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

Contact Info

Product

Resources

About