Triple Symptom Complex of Behcet

A Historical Review of Early Descriptions of Adamantiades-Behçet's Disease

“…In addition to the term ``triple symptom complex'' used by Behc Ëet (Behc Ëet, 1939b), Dascalopoulos proposed the term ``uveitis recidivans aphthosa'' (Dascalopoulos, 1941). From 1940 to 1950, cases from Italy (Cavara, 1940), Denmark (Bechgaard, 1941;Jensen, 1941a, b), Palestine (Berlin, 1944;Ephraim, 1944), and the U.S.A. (Ollendorff Curth, 1946b) were described for the ®rst time. In 1941, the Parisian dermatologist Touraine described 274 patients with not-infectious oral aphthosis ± among them were also patients with recurrent iritis with hypopyon (Touraine, 1941).…”

“…In 1941, Jensen from Denmark, being aware of Behc Ëet's work but not of that of Adamantiades, ®rst used the term ``Behc Ëet's syndrome'' to describe a patient with the triple symptom complex and ulcerous hemorrhagic colitis and established the pathergy test as a diagnostic criterion (Jensen, 1941a;1941b). In 1944, Berlin and Ephraim described simultaneously the disorder in necropsy material of a patient from Tel Aviv (Berlin, 1944) and in a patient from Haifa (Ephraim, 1944); both referred to the important work of Jensen and used the name of Behc Ëet in the titles of their publications. In 1946, Feigenbaum and Kornblu Èth ®rst used the term ``Behc Ëet's disease'' and considered it as a manifestation of a chronic septic condition connected with a constitutional disorder in their description of four additional patients from Jerusalem (Feigenbaum and Kornblueth, 1946).…”

Der Morbus Adamantiades-Behçet und seine Geschichte

“…[15]. Wenige Jahre später -1944taucht im Titel der Arbeiten von Berlin [29] and Ephraim [30], die über je einen Patienten aus Tel Aviv bzw. aus Haifa berichteten, der Namen von Behçet auf.…”

Regarding neutrophil and lymphocyte responses to oralStreptococcusin Adamantiades–Behçet's disease

“…Hulusi Behçet (1889–1948), however, was the first contemporary doctor who recognized a typical set of dermatologic, ocular and oro‐genital lesions, grouped all these findings himself into one disease, and then published the first results in 1937 (Behçet, 1937), and then diagnosed further patients and published in German as ‘Tri‐Symptomenkomplex’ (1939) Behçet (1939) and in English as ‘Triple symptom complex’ (1940) Behçet (1940). In subsequent years, this mystifying disorder drew the attention of the scientific community, and the term ‘Behçet syndrome’ was first used by Jensen (1941), the term ‘Triple symptom complex’ by Ephraim (1944) and ‘Behçet disease’ first by Feigenbaum & Kornblueth (1946). On 13 September 1947, international dermatological societies came together in Zurich and named the disease as ‘Morbus Behçet’, which honored the first describer of ‘triple symptom complex’, not individual symptoms.…”