Trimethylsilyl Cyanide (TMSCN)

Abstract

was born in 1988 in Puebla, Mexico. She obtained her B.Sc. degree in Chemistry (2011) and her M.Sc. degree in organic chemistry (2014) from Benemérita Universidad Autónoma de Puebla. Currently she works towards her Ph.D. under the guidance of Professor Sara Montiel Smith and Professor Penélope Merino Montiel. Her research focuses on the synthesis of steroidal spiro heterocycles.

Retracted: Porous GdIII‐Organic Framework as a Dual‐Functional Material for Cyanosilylation of Aldehydes and Ablation of Human Liver Cancer Cells

“…The anticancer activity of compounds 3 . It should be noted that only white deposition was obtained without the presence of HNO 3 , indicating the HNO 3 might act as a pH regulator which is very important for the formation of the water soluble Gd 3+ ions in the reaction process.…”

“…[2] Trimethylsilyl cyanide (TMSCN) is one of the most useful and safe cyanating reagents for nucleophilic addition to carbonyl compounds to give cyanohydrin trimethylsilyl ethers. [3] Hence, the development of efficient catalysts for cyanosilylation of carbonyl compounds with TMSCN is a very important subject in current research, and several efficient catalysts have been developed so far. During the past few decades, a lot of organic catalysts have been developed for the cyanosilylation of carbonyl compounds with TMSCN, but these catalysts suffer from some drawbacks such as tedious separation and recycle problems, which restrict their practical applications.…”

“…Generally, the addition of cyanide to carbonyl compounds is one of the most useful approaches for the preparation of cyanohydrins and has frequently been at the forefront of synthetic chemistry . Trimethylsilyl cyanide (TMSCN) is one of the most useful and safe cyanating reagents for nucleophilic addition to carbonyl compounds to give cyanohydrin trimethylsilyl ethers . Hence, the development of efficient catalysts for cyanosilylation of carbonyl compounds with TMSCN is a very important subject in current research, and several efficient catalysts have been developed so far.…”

“…As an emerging class of crystalline material that composed of metal modes and organic connectors, metal-organic frameworks (MOFs) have gained great interests for their wide range of potential applications as functional materials in gas storage/ analysis reveals that compound 1 is composed of 1D helical chain secondary building units that connect by the bpt 3ligands into a 3D framework with 1D nanosized channels running along the b axis. In view of its high porosity and accessible open metal sites, the activated 1 (1a) was studied for the cyanosilylation of aldehydes under solventfree conditions.…”

Pd-Catalyzed Allylic Isocyanation: Nucleophilic N-Terminus Substitution of Ambident Cyanide

“…According to the traditional Kornblum’s rule, which is applied for prediction of the regioselectivity of ambident nucleophiles, the N -terminus of cyanide preferentially reacts in the S N 1-type substitution. However, even in those reactions, the C -terminus of the cyanide reacts prior to the N -terminus, because the formation of the nitrile is both kinetically and thermodynamically more favorable in most cases. ,− Therefore, development of a selective synthetic method of isonitrile by the nucleophilic substitution is highly desirable . Realizing such a method by the catalytic procedure is more challenging.…”