Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating <scp>TNF</scp>‐α, <scp>BAX</scp>, and <scp>VEGF</scp> immunoexpression via an antioxidant mechanism

Eid, Basma G.; El-Shitany, Nagla A.; Neamatallah, Thikryat

doi:10.1002/tox.23120

Cited by 10 publications

(12 citation statements)

References 41 publications

(70 reference statements)

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“…Similarly, the current study findings validate the inflammatory process associated with doxorubicin-induced cardiotoxicity, as seen by a significant rise in cardiac IL-1β and TNF-α in the doxorubicin group over the control group. These findings are consistent with other investigations (Alyasiry et al, 2022;Aziz et al, 2020;Eid et al, 2021;Rusul et al, 2022). Isosorbide dinitrate markedly decreased the elevated proinflammatory markers IL-1β and TNF-α in rats compared to the induced untreated doxorubicin group.…”

Section: Resultssupporting

confidence: 94%

Isosorbide dinitrate improves doxorubicin-induced cardiotoxicity via diminishing proinflammatory mediators, oxidative stress, and apoptosis

2023

JPTCP

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Cardiotoxicity is the presence of cardiac dysfunction resulting from electrical or muscle injury, which results in heart toxicity. The heart weakens and becomes less efficient in pumping blood. Cardiotoxicity is one of chemotherapy most serious side effects, with significantly increased morbidity and mortality. Isosorbide dinitrate is an antianginal agent used to treat chest pain in people with a certain heart condition (coronary artery disease). This medication belongs to the nitrate drug class. It works by relaxing and widening blood vessels, allowing more blood to flow to the heart. The role of isosorbide dinitrate in doxorubicin-induced cardiotoxicity reduction or prevention is briefly discussed in this work. The 28 male rats were randomly split into four groups (7 rats in each group). The control group of rats was provided with natural food and drink. For two weeks, rats in the normal saline group were fed 0.9% normal saline. For those in the doxorubicin-induced group, 2.5 mg/kg was administered thrice weekly to the rats for two weeks. ISDN group (treated with ISDN): ISDN was administered orally (10 mg/kg/d) for two weeks. Heart damage was a result of doxorubicin treatment. Cardiac tissues of doxorubicin-treated rats showed elevated tumor necrosis factor-alpha, interleukin-1beta, malondialdehyde, and caspase-3 levels (p<0.05), while total antioxidant capacity and Bcl-2 levels were considerably decreased (P<0.05). Inflammatory markers (TNF-α and IL-1β) are reduced after ISDN treatment, providing strong evidence that ISDN considerably mitigates doxorubicin-induced cardiotoxicity (P<0.05). In addition, total antioxidant capacity was considerably increased in the ISDN group compared to the doxorubicinonly group (P<0.05), whereas the oxidative marker malondialdehyde in cardiac tissue was decreased (P<0.05). ISDN dramatically mitigated doxorubicin-induced cardiotoxicity in rats by modulating oxidative stress, the inflammatory response, and the apoptotic pathway. This research aimed to see if ISDN may prevent doxorubicin-induced cardiotoxicity by limiting the effects of the medication on inflammation pathways, oxidative pathways, and apoptotic pathways.

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Section: Resultssupporting

confidence: 94%

Isosorbide dinitrate improves doxorubicin-induced cardiotoxicity via diminishing proinflammatory mediators, oxidative stress, and apoptosis

2023

JPTCP

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“…Additionally, it was reported that trimetazidine (TMZ), a piperazine derivative, mediated activation of the GSH system and had antioxidant and cytoprotective effects in several myocardial injury models [210][211][212][213]. For instance, in the myocardium of exhaustive-exercised rats, TMZ produced specific cardioprotective outcomes by increasing GSH and GPX activity to clear oxidative stress.…”

Section: Glutathione System Activatormentioning

confidence: 99%

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Tan

Yin

et al. 2023

Cell Death Dis

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The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury. Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury. Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage. Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy. In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches.

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“…В 2020 и 2021гг консультантами чаще назначалась дополнительная кардиопротекторная терапия триметазидином и фосфокреатином как при подготовке к хирургических вмешательствам, так и при проведении лекарственной терапии. В основе профилактического и лечебного действия триметазидина при кардиотоксичности, вызванной противоопухолевой терапией, лежат антиоксидантный, противовоспалительный и антиапоптотический эффекты препарата, обусловленные его влиянием на дыхательную цепь в митохондриях [19]. Использование фосфокреатина при ХТ больных раком молочной железы уменьшает повреждение миокарда и приводит к снижению уровней сердечного тропонина Т и С-реактивного белка [20].…”

Section: цель консультацииunclassified

Telehealth consultations in cardio-oncology

Potievskaya

Kononova

Shaputko³

et al. 2022

Cardiovasc Ther Prev

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Aim. To evaluate the role of a cardiologist in telehealth counseling of cancer patients at the federal oncology center.Material and methods. This retrospective study was conducted based on the materials of 215 telehealth consultations on cardiooncology, performed in the period from January 2019 to September 2021. Data on referrals to a cardiologist (cardio-oncologist) from various Russian regions and consultants’ answers were analyzed, taking into account the following data: region, sex, age of a patient, cancer type, stage, participation of other consultants, type of cardiovascular disease, the need for additional information and features of treatment — surgery, chemotherapy, radiation therapy. Risk was stratified based on a checklist including the main risk factors for cardiotoxicity. The recommendations of consultants for monitoring patients, as well as drug therapy prescriptions, were analyzed.Results. The most common cancer sites in patients referred for telehealth consultations on cardio-oncology were lungs, larynx and trachea, colon and rectum, kidneys and bladder, ovaries and uterus, and stomach. Cardiologists consulted together with oncologists — surgeons, medical oncologists, as well as anesthesiologists and radiation oncologists. The most common cardiovascular diseases were hypertension — 80,9% of patients, heart failure — 60%, arrhythmias — 41,6% and coronary heart disease — 37,7%. From 71 to 80,3%, 15,6-21% and 3,9-7,8% of patients had preserved, mid-range and reduced left ventricular ejection fraction. In 47,6-66,7% of cases, consultants required additional information. Based on risk stratification of cardiotoxicity of anticancer treatment, 118 (81,9%) patients out of 144 were classified as high and very high risk. Most patients were recommended cardioprotective therapy, which most often included angiotensin-converting enzyme inhibitors/angiotensin receptor blockers — 43,1-53,1%, beta-blockers — 44,8-58,6%, and statins — 22,4-38,3%. An algorithm for creating a request for a cardio-oncology telehealth consultation has been developed.Conclusion. The important role of cardio-oncology telehealth consultations in the work of the federal oncology center is demonstrated. Consulting cardiologists are part of a single multidisciplinary team of specialists and must act taking into account the characteristics of cancer and antitumor therapy prescribed by oncologists.

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Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism

Cited by 10 publications

References 41 publications

Isosorbide dinitrate improves doxorubicin-induced cardiotoxicity via diminishing proinflammatory mediators, oxidative stress, and apoptosis

Isosorbide dinitrate improves doxorubicin-induced cardiotoxicity via diminishing proinflammatory mediators, oxidative stress, and apoptosis

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Telehealth consultations in cardio-oncology

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