Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: Implications for bisphenol A developmental toxicity

Pelayo, Sergi; Oliveira, Eva; Thienpont, Benedicte; Babin, Patrick J.; Raldúa, Demetrio; André, Michèle; Piña, Benjamı́n

doi:10.1016/j.aquatox.2011.12.016

Cited by 45 publications

(21 citation statements)

References 49 publications

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“…The connection of these metabolites with other pathways related to secondary metabolites (2,3-butanediol, tartrate, glycerate) may suggest an effect on the plants’ secondary metabolism, possibly related to their defence mechanisms, as occurs with embryos exposed to BPA 39–43 .…”

Section: Resultsmentioning

confidence: 99%

Linking the morphological and metabolomic response of Lactuca sativa L exposed to emerging contaminants using GC × GC-MS and chemometric tools

Hurtado

Parastar

Matamoros

et al. 2017

Sci Rep

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The occurrence of contaminants of emerging concern (CECs) in irrigation waters (up to low μg L−1) and irrigated crops (ng g−1 in dry weight) has been reported, but the linkage between plant morphological changes and plant metabolomic response has not yet been addressed. In this study, a non-targeted metabolomic analysis was performed on lettuce (Lactuca sativa L) exposed to 11 CECs (pharmaceuticals, personal care products, anticorrosive agents and surfactants) by irrigation. The plants were watered with different CEC concentrations (0–50 µg L−1) for 34 days under controlled conditions and then harvested, extracted, derivatised and analysed by comprehensive two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer (GC × GC-TOFMS). The resulting raw data were analysed using multivariate curve resolution (MCR) and partial least squares (PLS) methods. The metabolic response indicates that exposure to CECs at environmentally relevant concentrations (0.05 µg L−1) can cause significant metabolic alterations in plants (carbohydrate metabolism, the citric acid cycle, pentose phosphate pathway and glutathione pathway) linked to changes in morphological parameters (leaf height, stem width) and chlorophyll content.

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Section: Resultsmentioning

confidence: 99%

Linking the morphological and metabolomic response of Lactuca sativa L exposed to emerging contaminants using GC × GC-MS and chemometric tools

Hurtado

Parastar

Matamoros

et al. 2017

Sci Rep

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“…In chicks, expressions of thyroid receptors and deiodinases are directly associated with the progression of retinal development (Trimarchi et al, 2008). Further, genetic studies show that external administration of T3 changes expression of retina-related genes (Peleyo et al, 2012), and evidence suggests that the thyroid receptor ␤2 (tr␤2) gene is important for correct cone opsin expression (Suzuki et al, 2013). A recent study in zebrafish found that phenylthiourea, a pigment suppressor that affects thyroxine levels, reduces lens and eye size .…”

Section: Introductionmentioning

confidence: 97%

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

Reider

Connaughton

2014

Birth Defects Research Pt B

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Thyroid hormones are required for vertebrate development, and disruption of the thyroid system in developing embryos can result in a large range of morphologic and physiologic changes, including in the eye and retina. In this study, our anatomic analyses following low-dose, chronic thyroid inhibition reveal that both methimazole (MMI) exposure and rearing temperature affect eye development in a time- and temperature-dependent fashion. Maximal sensitivity to MMI for external eye development occurred at 65 hr postfertilization (hpf) for zebrafish reared at 28°C, and at 69 hpf for those reared at 31°C. Changes in eye diameter corresponded to changes in thickness of two inner retinal layers: the ganglion cell layer and the inner plexiform layer, with irreversible MMI-induced decreases in layer thickness observed in larvae treated with MMI until 66 hpf at 28°C. We infer that maximal sensitivity to MMI between 65 and 66 hpf at 28°C indicates a critical period of thyroid-dependent eye and retinal development. Furthermore, our results support previous work that shows spontaneous escape from MMI-induced effects potentially due to embryonic compensatory actions, as our data show that embryos treated beyond the critical period generally resemble controls.

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“…The use of these models for thyroid disruption is still incipient, but steadily growing, both in laboratory studies (Corcoran et al, 2012;Pelayo et al, 2012;Thienpont et al, 2011) and in natural populations' surveys Schnitzler et al, 2012;Picard-Aitken et al, 2007). Brown et al (2004a) reviewed the potential contaminants that may impact the thyroid system in teleost fish.…”

Section: Introductionmentioning

confidence: 98%

Deiodinases and thyroid metabolism disruption in teleost fish

Jarque

Piña

2014

Environmental Research

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Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: Implications for bisphenol A developmental toxicity

Cited by 45 publications

References 49 publications

Linking the morphological and metabolomic response of Lactuca sativa L exposed to emerging contaminants using GC × GC-MS and chemometric tools

Linking the morphological and metabolomic response of Lactuca sativa L exposed to emerging contaminants using GC × GC-MS and chemometric tools

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

Deiodinases and thyroid metabolism disruption in teleost fish

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