Tricyclic Derivative of Acyclovir and Its Esters in Relation to the Esters of Acyclovir Enzymatic Stability: Enzymatic Stability Study

Muszalska-Kolos, Izabela; Lesniewska-Kowiel, Monika A.; Plewa, Szymon; Klupczyńska, Agnieszka

doi:10.3390/molecules25092156

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Thus, aspirin is hydrolyzed by BChE to salicylic acid and acetic acid [21]. Plasma BChE also hydrolyzes the prodrugs of antiviral agents, e.g., oseltamivir phosphate (Tamiflu) [22] and acyclovir esters [23]. Irinotecan, an anticancer drug approved for colon cancer treatment, forms an active metabolite, SN-38 [24].…”

Section: Cholinesterase and Anticholinesterase Agents 21 Cholinesterasesmentioning

confidence: 99%

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Ivanov,

Shamagsumova,

Larina

et al. 2024

Biosensors

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Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed.

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Section: Cholinesterase and Anticholinesterase Agents 21 Cholinesterasesmentioning

confidence: 99%

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Ivanov,

Shamagsumova,

Larina

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

“…Aspects related with the determination of pollutants as persistent organic pollutants or polycyclic aromatic hydrocarbons in different samples are also covered [ 9 , 10 ]. Finally, this collection provides information on the stability to enzymatic degradation of the tricyclic acyclovir derivative and its esters (acetyl, isobutyryl, pivaloyl, nicotinic, ethoxycarbonyl) compared with the stability of analogue acyclovir esters [ 11 ], as well as a mechanistic study on homogenous charge compression ignition engines [ 12 ]. The twelve manuscripts published in the current Special Issue cover almost all aspects of Green Chemistry.…”

mentioning

confidence: 99%