2018
DOI: 10.3892/ol.2018.9641
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Abstract: Trichostatin A (TSA) has been demonstrated to exhibit various anticancer effects that influence cell cycle arrest, cell proliferation and apoptosis of cancer cells. A potential association between TSA and endoplasmic reticulum (ER) function has been suggested but its anticancer mechanism involving the induction of ER stress is unknown. p53 has previously been demonstrated to regulate ER function in response to stress but its role involving TSA and ER stress in cancer cells is poorly understood. The current stu… Show more

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Cited by 7 publications
(7 citation statements)
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“…TSA is a complete class I and II HDACs inhibitor [ 26 , 28 ], which was originally used as an antimycotic [ 29 ]. It increases histone acetylation and consequently has a strong impact on oxidative stress, cell cycle arrest, apoptosis [ 28 , 30 , 31 ], and epithelial–mesenchymal transition [ 32 ]. Its anti-tumor effect has been shown in multiple types of cancer, such as, colon, breast, prostate and esophageal squamous cells [ 28 , 30 , 31 ].…”
Section: Introductionmentioning
confidence: 99%
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“…TSA is a complete class I and II HDACs inhibitor [ 26 , 28 ], which was originally used as an antimycotic [ 29 ]. It increases histone acetylation and consequently has a strong impact on oxidative stress, cell cycle arrest, apoptosis [ 28 , 30 , 31 ], and epithelial–mesenchymal transition [ 32 ]. Its anti-tumor effect has been shown in multiple types of cancer, such as, colon, breast, prostate and esophageal squamous cells [ 28 , 30 , 31 ].…”
Section: Introductionmentioning
confidence: 99%
“…It increases histone acetylation and consequently has a strong impact on oxidative stress, cell cycle arrest, apoptosis [ 28 , 30 , 31 ], and epithelial–mesenchymal transition [ 32 ]. Its anti-tumor effect has been shown in multiple types of cancer, such as, colon, breast, prostate and esophageal squamous cells [ 28 , 30 , 31 ]. TSA has on its own induced the suppression of angiogenesis and metastasis in cancer cells, as well as the suppression of vasculogenic mimicry in glioblastoma cell lines [ 29 , 30 , 33 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Specifically, trichostatin-a that belongs to the class of organic compounds and it is used as an antifungal antibiotic, regulates the expression of three monotonically over-expressed genes (SNTB1, TACSTD2 and HSPH1) and two under-expressed (SLC26A2 and CLCA1). It has been reported that trichostatin-a has anticancer effects in the domain of cell proliferation and apoptosis and it has been suggested as possible therapy for colon cancer (35). Moreover, vorinostat, a member in the family of compounds that inhibit HDAC and also used in the management of cutaneous T cell lymphoma, was found to influence the expression of two overand one under-monotonically expressed gene SNTB1, TACSTD2 and SLC26A2 respectively.…”
Section: Discussionmentioning
confidence: 99%
“…Also, the activity of ATF6 was shown to be promoted by mutp53 leading to an adaptive output with higher cell aggressiveness in Matrigel invasion assays [124]. While these observations support the idea of a direct role of p53 in the control of the three UPR sensors, the mechanisms involved and the role of p47 are scarcely known, and thus require closer attention [124,125]. However, they still emphasize the importance to develop therapeutic strategies aiming to restore the normal activity of p53 in cancer cells and/or to remove the GOF properties linked to mutp53, thus activating the ER stress-dependent death pathways.…”
Section: Therapeutic Approaches Based On P53mentioning
confidence: 97%