Trichofolliculoma showing perineural invasion. Trichofolliculocarcinoma?

Stern, J. B.

doi:10.1001/archderm.115.8.1003

Cited by 30 publications

(36 citation statements)

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“…2,9 Although TF is a benign tumor, Stern et al reported the perineural invasion of it. 10 Trichoepithelioma (TE) is a benign, cutaneous mesenchymal tumor originating from germ layer of hair follicle. [11][12][13] Trichoblastoma (TB) is extremely rare benign tumors located deep dermis and subcutis.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

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Differential diagnosis between benign tumors of cutaneous appandages originating from hair follicle (BTCOHF) (trichoadenoma [TA], trichofolliculoma [TF], trichoepithelioma [TE] and trichoblastoma [TB]) and basal cell carcinoma (BCC) have been tedious for the pathologists, especially in the presence of small specimens to date. Thirty cases of BTCOHF and 30 cases of BCC were retrieved from the archives, deposited from 2004 to 2008. Age, sex, localisation and histopathological characters such as ulceration, pigmentation, inflammation, and cyst formation were comparatively evaluated between both groups and each subgroups. No significant diference was detetected between two groups in the rate of the age, sex and the histopathology. Besides, histopathological characters were not significant for the subgroups of BCC. However, ulceration was observed in TE (Of 21 cases 5, [23.8%]) and TB (All the 5 cases, [100%]), but not in TA and TF which are the subgroups of BTCOHF and the difference was significant (p= 0,005). But, pigmentation, inflammation and cyst formation were not significant among the subgroups of both groups. We can conclude that BCC and BTCOHF may not be discriminated concerning age, sex and histopathological characters including ulceration, pigmentation, inflammation, and cyst formation. Secondly, one may not make the differential diagnosis easily even between the subgroups of each group via evaluating the histopathological characters, so that might create some life-threatening unwelcome outcomes. Keywords: Basal cell carcinoma, Pigmentation, Inflammation, Histopathology ÖZET Histopatolojik karakterler Bazal Hücreli Karsinoma ile K›l Follikülünden Köken Alan Benign Deri Eki Tümörlerinin Ay›r›c› Tan›s›nda Yararl› OlamayabilirTrikoadenoma, trikofolliküloma, trikoepitelyoma ve trikoblastoman›n bazal hücreli karsinomadan ay›r›c› tan›s›, bugüne kadar özellikle küçük spesimenlerde patologlar için can s›k›c› ve usand›r›c› olmaya devam edegelmifltir. Otuz k›l follikülünden köken alan benign deri eki tümörleri olgusu ve 30 bazal hücreli karsinoma olgusu, 2004 -2008 y›llar› aras›nda depoland›¤› arflivden yeniden edinildi. Yafl, cinsiyet, lokalizasyon ve ülserasyon, pigmentasyon, inflamasyon ve kist formasyonu gibi histopatolojik karekterler her iki grup ve her subgrup aras›nda karfl›laflt›rmal› olarak de¤erlendirildi. Yafl, cinsiyet, lokalizasyon ve histopatoloji aç›s›ndan iki grup aras›nda anlaml› fark saptanmad›. Ayr›ca, histopatolojik karekterler bazal hücreli karsinoman›n subgruplar› için anlaml› de¤ildi. Bununla birlikte; ülse-rasyon, k›l follikülünden köken alan benign deri eki tümörlerinin subgruplar› olan trikoepitelyoma (21 olgunun 5'inde [%23.8]) ve trikoblastomada (5 olgunun tümünde [%100]) izlendi, ancak trikoadenoma ve trikofollikülomada izlenmedi ve bu fark anlaml› bulundu (p= 0.005). Pigmentasyon, inflamasyon ve kist formasyonu her iki grubun subgruplar› aras›nda anlaml› de¤ildi.

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Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

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“…The presence of a wool-like tuft of white hair protruding from the pore is clinically useful in suggesting the diagnosis. 42,43 Histologically, trichofolliculoma is composed of one or more dilated follicles, with smaller secondary and tertiary follicles radiating from it, all developing within a cellular connective tissue stroma. The central follicle, which typically opens to the surface, may contain vellus hair.…”

Section: Trichofolliculomamentioning

confidence: 99%

“…These authors noted PNI to be unusual with uncertain importance. 42 They stated that evidence exists for both a negative and nonprognostic value associated with PNI. There are no reports of recurrence after local excision; however, long-term follow-up is needed.…”

Section: Trichofolliculomamentioning

confidence: 99%

Perineural Involvement: What Does it Mean?

Ronaghy

Yaar²,

Goldberg³

et al. 2010

The American Journal of Dermatopathology

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Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality. Thus, perineural invasion is often used both as a marker of malignancy and an indicator of aggressive behavior. There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it. Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves. Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement. The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement. Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.

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“…1 SAT may display more than one line of differentiation (hybrid/composite tumours), rendering precise classification of these neoplasms difficult. 2 The diagnosis of these mixed SAT relies on histological evaluation, and they are usually classified according to the predominant morphological component.…”

Section: Introductionmentioning

confidence: 99%

Malignant adnexal tumors: a rare case of cutaneous malignancy

2017

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Skin adnexal tumours (SAT) are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation towards one of the different types of adnexal epithelium present in normal skin: pilosebaceous unit, eccrine and apocrine. In present case, a forty-five-year-old female patient presented to us with a solitary erythematous swelling over the left chest wall since two years, which was approximately 3 × 3 cm in size, slowly growing to its present size of 10X5 cm, painless, hard in consistency with smooth erythematous surface, non-mobile and not associated with discharge or axillary lymphadenopathy.

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Trichofolliculoma showing perineural invasion. Trichofolliculocarcinoma?

Abstract: Short Reports usually concern a single case report.

Cited by 30 publications

References 0 publications

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Perineural Involvement: What Does it Mean?

Malignant adnexal tumors: a rare case of cutaneous malignancy

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