Trichoblastic fibroma. A series of 10 cases with report of a new plaque variant

Altman, David A.

doi:10.1001/archderm.131.2.198

Cited by 23 publications

(36 citation statements)

References 9 publications

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“…Low-grade trichoblastic carcinomas appear to be slowly enlarging, smaller than high-grade, plaques or nodules occur on the face, and do not recur if excised completely (2,(4)(5)(6). Among the cases of low-grade trichoblastic carcinoma shown in Table I variant of trichoblastic fibroinas" and the case reported by Cowen et al (5) was originally named an "unusual aggressive trichoblastoma".…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review

Lee¹,

Kim²,

Cho³

et al. 2008

Acta Derm Venereol

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Patients with the autosomal-dominant form of multiple familial trichoepithelioma develop numerous tumours on the face, neck and upper trunk, beginning in childhood. Malignant transformation of such lesions is quite rare; only one case of "malignant trichoepithelioma" has been reported previously, inferring pilomatrix carcinoma on a histological observation. We report here the case of a patient who developed a malignant neoplasm in a long-standing trichoepithelioma lesion on her buttock. Histopathology revealed a transformation zone between the trichoepithelioma and a malignant tumour mass. This case also showed several features of a malignant neoplasm of trichoblastic origin.

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Section: Discussionmentioning

confidence: 99%

Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review

Lee¹,

Kim²,

Cho³

et al. 2008

Acta Derm Venereol

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“…Incidentally, the malignant transformation occurred after the patient developed chronic lymphocytic leukemia. In 1995 Altman et al 10 described three examples of a locally aggressive plaque variant of trichoblastic fibroma and suggested that these cases may be of low-grade malignant potential. Another example of locally aggressive trichoblastoma was recently reported by Cowen et al 11 on the chin of a 47-year-old man.…”

Section: Discussionmentioning

confidence: 99%

Trichoblastic Carcinoma: A Report of Two Cases of a Deeply Infiltrative Trichoblastic Neoplasm

et al. 2001

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“…Histologically, this rare neoplasm is characterized by its deep dermal or subcutaneous location, fronds and strands of basaloid cells which are considered equivalent to the hair germ cells, with peripheral palisading of the nuclei, keratinous cysts, and a dense cellular and fibroblastic stroma 1 –8 . In some cases, mitoses are easily identified and a focal necrosis or apoptosis can be observed in the basaloid nests 3 ,.…”

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confidence: 99%

“…In some cases, mitoses are easily identified and a focal necrosis or apoptosis can be observed in the basaloid nests 3 ,. 4 Trichoepithelioma is a benign cutaneous epithelial–mesenchymal tumour with pilar differentiation best regarded as hair germ hamartoma 1 ,. 9 Clinically, this tumour occurs either as multiple lesions, i.e.…”

mentioning

confidence: 99%

Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma

Yamamoto

Asahi

1999

British Journal of Dermatology

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Classical trichoblastic fibroma or small nodular type trichoblastoma (Ackerman) is a rare tumour. This tumour, trichoepithelioma and basal cell carcinoma (BCC) have some overlapping histopathological features. There are only a few reports on immunohistochemical studies in large series of these three neoplasms. We investigated immunostaining patterns of 10 different anticytokeratin (CK) antibodies and several other markers in these neoplasms, comparing them with the patterns in normal adult and fetal skin. In trichoblastic fibroma (three cases), CK1/5/10/14, CK7, CK8/18, CK10/11, CK14, CK17 and CK19 were expressed in the basaloid nests, and CK6 and involucrin were detected in the inner layers of keratinous cysts. Trichoepithelioma (seven cases) expressed CK1/5/10/14, CK8/18, CK14, CK17 and CK19 in the basaloid nests, and CK6, CK10, CK10/11 and involucrin were positive in the keratinous cysts. However, no CK7 expression was observed. Solid and keratotic types of BCC (29 cases) expressed CK1/5/10/14, CK7, CK8/18, CK14, CK17 and CK19 in the basaloid nests. The keratinous cysts in BCC were stained with anti-CK6, CK10, CK10/11 and involucrin antibodies. Coupled with the expression of CK8/18, CK17 and CK19 in the outer root sheath of the adult hair follicle, these three neoplasms shared a keratin phenotype characteristic of the outer root sheath. Judging from our immunohistochemical results, trichoblastic fibroma and BCC cannot be differentiated by their patterns of CK expression. The expression of CK7, which is noted in fetal hair follicles, trichoblastic fibroma and BCC, suggests the presence of subpopulations that retain fetal phenotypic characteristics in these two neoplasms. Although the current concept regards trichoepithelioma and trichoblastic fibroma as a single tumour group, the lack of CK7 expression in trichoepithelioma supports the notion that the two are different.

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Trichoblastic fibroma. A series of 10 cases with report of a new plaque variant

Cited by 23 publications

References 9 publications

Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review

Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review

Trichoblastic Carcinoma: A Report of Two Cases of a Deeply Infiltrative Trichoblastic Neoplasm

Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma

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