Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos

Zhang, Jiliang; Zuo, Zhenghong; Sun, Peng; Wang, Hongwei; Yu, Ang; Wang, Chonggang

doi:10.1016/j.marenvres.2011.12.008

Cited by 33 publications

(15 citation statements)

References 41 publications

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“…The inhibition of this enzyme activity produces membrane depolarization, leading to the suppression of neuronal and excitatory transmission (Albrecht and Hilgier, ; Zhang et al, ). Zhang et al () reported that TBT exposure inhibited the ATPase in brain of rockfish embryos. In this study, the TBT‐induced inhibition of Na + ‐K + ‐ATPase in fish brain probably disturbs Na + ‐K + pump, resulting in a erratic entry of Na + into the cell along the concentration gradient and the water molecule follows along the osmotic gradient (Oruc et al, ).…”

Section: Resultsmentioning

confidence: 99%

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Shi

2015

Environ. Toxicol.

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Tributyltin (TBT), as antifouling paints, is widely present in aquatic environment, but little is known regarding the toxicity of TBT on fish brain. In this study, the effects of exposure to TBT on the antioxidant defense system, Na(+) -K(+) -ATPase activity, neurological enzymes activity and Hsp 70 protein level in brain of juvenile common carp (Cyprinus carpio) were studied. Fish were exposed to sublethal concentrations of TBT (5, 10 and 20 μg/L) for 7 days. Based on the results, with increasing concentrations of TBT, oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, as well as the significant inhibition of all antioxidant enzymes activities. Besides, the activities of Acetylcholinesterase (AChE), Monoamine oxidases (MAO) and Na(+) -K(+) -ATPase were significantly inhibited after exposure to TBT with higher concentrations. In addition, the levels of Hsp 70 protein were evaluated under TBT stress with dose-depended manner. These results suggest that selected physiological responses in fish brain could be used as potential biomarkers for monitoring residual organotin compounds present in aquatic environment.

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Section: Resultsmentioning

confidence: 99%

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Shi

2015

Environ. Toxicol.

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“…In this study, the inhibition of Na‐K‐ATPase in all fish tissues after long‐term exposure probably disturbs the Na‐K pump, resulting in an erratic entry of Na + into the cell along the concentration gradient and the water molecule follows along the osmotic gradient (Oruc et al, ). Zhang et al () reported that TBT exposure inhibited the ATPase in brain of rockfish embryos. In the current study, the activity of ATPase in gill tissue showed more sensitive to the TBT, probably due to its physiological structure and functions.…”

Section: Discussionmentioning

confidence: 99%

Chronic effects of tributyltin on multiple biomarkers responses in juvenile common carp, Cyprinus carpio

Shi

2015

Environmental Toxicology

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In this study, the chronic toxic effects of tributyltin (TBT), an antifouling paints commonly present in surface and ground water, on morphological indices, reactive oxygen species (ROS) generation, and ATPase activity and heat shock protein (Hsp) 70 protein in tissues (liver, gill, and white muscle) of common carp were investigated. Fish were exposed at sublethal concentrations of TBT (75 ng/L, 0.75 μg/L, and 7.5 μg/L) for 60 days. When compared with the control, there was significant lower condition factor in fish exposed at the higher concentration of TBT. ROS levels in three tissues increased significantly at higher TBT concentrations (0.75 and 7.5 μg/L). The hepatic antioxidant enzymes (total antioxidative capacity and superoxide dismutase) activities were induced at higher concentrations (0.75 μg/L) of TBT. When compared with the hepatic antioxidant enzymes activities in fish exposed to 0.75 μg/L of TBT, there was a decreasing trend in those exposed to TBT with a concentration of 7.5 μg/L. However, all the antioxidant enzymes activities were significantly inhibited in gill and muscle of fish exposed to higher TBT concentrations (0.75 and 7.5 μg/L). Moreover, there was significant lower Na-K-ATPase in three tissues after long-term exposure to higher concentration of TBT, but a significant higher Hsp70 protein levels was observed. In short, environmental concentrations of TBT could not induce obvious impacts on fish, but long-term exposure to higher concentrations of TBT could affect seriously the health status of fish. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 937-944, 2016.

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“…Not surprisingly, fetal rat testes exposed ex vivo to cyclopamine show significant downregulation of HH pathway genes and other Leydig-cell specific genes, also indicating a general loss if differentiated Leydig cells ( Brokken et al, 2009 ). Other examples include the insecticide synergist piperonyl butoxide ( Wang, et al, 2012 ), the photolytic compounds of the insecticide methoprene ( Smith et al, 2003 ) and the biocide tributyltin ( Zhang et al, 2012 ), which all have been shown to inhibit HH signaling and cause severe developmental defects in fish. In rats, developmental exposure to DEHP was recently shown to downregulate Shh in male offspring, causing impaired neuromotor development ( Fu et al, 2019 ), whereas intrauterine exposure to DBP can inhibit HH signaling and impair male reproductive development ( Kim et al, 2010 ).…”

Section: Hh Disrupting Chemicalsmentioning

confidence: 99%

Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals?

Johansson

Svingen

2020

Current Research in Toxicology

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Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos

Cited by 33 publications

References 41 publications

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Chronic effects of tributyltin on multiple biomarkers responses in juvenile common carp, Cyprinus carpio

Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals?

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