Triamcinolone Acetonide Cream in a Double-Blind Test

Influence of Local Triamcinolone Acetonide on Patch Test Reactions to Nickel Sulfate

“…Never theless, it seems justified to conclude tentatively that triamcinolone acetonide has a greater inhibitory action on the patch test reaction than does hydro cortisone acetate. This is in accordance with the known higher activity of triamcinolone acetonide in clinical trials as compared with hydrocortisone [Polano, 1961], Our results are not in complete agreement with those of Scott [1965] who found complete inhibition of the reaction to dinitrochlorobenzene in sensitized guinea pigs after prior epicutaneous application of triamcinolone acetonide. Here differences in structure of human and guinea pig skin probably played a role such that higher tissue concentrations could be achieved locally in the guinea pig.…”

Triamcinolone and Fluocinolone Acetonide Ointments in Atopic Eczema

“…This drug is chemically 6a-9a-difluoro-1 6-hydroxyprednisolone 16,1 7-acetonide. Encouraging reports on its use have already been reported from the United States, such as that by Robinson (1961), who found that this application was as effective as 0.1 % triamcinolone acetonide and superior to 1% hydrocortisone in diseases normally responsive to local steroid treatment.…”

“…More recently ointments, creams, and lotions containing 0.1 % triamcinolone acetonide have been found to be more effective than those containing hydrocortisone (Smith, Zawisza, and Blank, 1958;Vickers and Tighe, 1960;Polano, 1961). Therefore it was thought worth while attempting a comparison between the proved effects of 0.…”