Triamcinolone Acetonide — A Highly Effective New Topical Steroid

Fluocinolone Acetonide, A New Topical Corticosteroid: Clinical and Pharmacologic Evaluation

“…This latter undesirable feature is compensated for by formation of the 16,17-acetonide (IV), with the resulting compound having markedly increased topical activity. 3,4,5 These observations suggested that further modification, with formation of the 6a,9a-difluoro-16a-hydroxyprednisolone (V) and, for topical use, the corresponding 16,17-acetonide (VI), might be expected to combine highest antiinflammatory action with low sodium retention. This new corticosteroid, fluocinolone acetonide (VI), was synthesized.…”

A new topical

“…TCS were introduced back in 1952, when Sulzberger and Witten reported that compound F ointment – that is 17‐hydroxycortisone‐21‐acetate – led to improvement of various skin diseases, including atopic dermatitis 1 . In the decades following Sulzberger’s and Witten’s landmark publication, more potent corticosteroid preparations have been developed, such as triamcinolone acetonide and betamethasone valerate 2,3 . TCS quickly became established as the mainstay topical therapy for atopic dermatitis and their indication was expanded to other inflammatory skin diseases.…”

Topical and Intralesional Administration of Triamcinolone Acetonide: Advantages in Dermatologic Therapy

“…There is no longer any question about the preferential use of corticosteroids, alone or in combination with antibiotics, in the treatment of various skin diseases (1–28). These agents have proven decisive in many clinical states in which the associated inflammation and pruritus are of compelling importance.…”