Trial of neurodynamic treatment was reported accurately and appropriately

Ferreira, Giovanni E; Stieven, Fábio Franciscatto; Araújo, F. X. de; Wiebusch, Matheus; Rosa, Carolina Gomes; Plentz, Rodrigo Della Méa; Silva, Marcelo

doi:10.1016/j.jphys.2016.11.004

Cited by 1 publication

(1 citation statement)

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“…The underlying mechanisms of neural mobilization interventions include the restoration of homeostasis in and around the nerves and attenuation of intraneural edema through intraneural fluid dispersion in the nerve root and axon (Boudier-Revéret et al, 2017). Neurodynamic treatment demonstrated a significant reduction in leg pain intensity and improved function after 4 weeks of intervention in patients with chronic SC (Ferreira et al, 2016). The current trial provides strong evidence for the effectiveness of these two methods on SC.…”

Section: Potential Physical Meansmentioning

confidence: 67%

Potential novel therapeutic strategies for neuropathic pain

Zhang

Han

et al. 2023

Front. Mol. Neurosci.

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PurposeTo explore the potential therapeutic strategies of different types of neuropathic pain (NP) and to summarize the cutting-edge novel approaches for NP treatment based on the clinical trials registered on ClinicalTrials.gov.MethodsThe relevant clinical trials were searched using ClinicalTrials.gov Dec 08, 2022. NP is defined as a painful condition caused by neurological lesions or diseases. All data were obtained and reviewed by the investigators to confirm whether they were related to the current topic.ResultsA total of 914 trials were included in this study. They were divided into painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), sciatica (SC), peripheral nerve injury-related NP (PNI), trigeminal neuralgia (TN), chemotherapy-induced NP (CINP), general peripheral NP (GPNP) and spinal cord injury NP (SCI-NP). Potential novel therapeutic strategies, such as novel drug targets and physical means, were discussed for each type of NP.ConclusionNP treatment is mainly dominated by drug therapy, and physical means have become increasingly popular. It is worth noting that novel drug targets, new implications of conventional medicine, and novel physical means can serve as promising strategies for the treatment of NP. However, more attention needs to be paid to the challenges of translating research findings into clinical practice.

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Section: Potential Physical Meansmentioning

confidence: 67%