Triacylglycerols compositions, soluble and bound phenolics of red sorghums, and their radical scavenging and anti-inflammatory activities

Li, Ming; Xu, Tao; Zheng, Wenhao; Gao, Boyan; Zhu, Hongyan; <, Xu Ruo-Fei; Deng, Han‐Yu; Wang, Bo; Wu, Yanbei; Sun, Xiaojiang; Zhang, Yaqiong; Yu, Liangli

doi:10.1016/j.foodchem.2020.128123

Cited by 41 publications

(44 citation statements)

References 38 publications

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“…Pro-inflammatory cytokines, such as interleukin 1, β (IL-1β), tumor necrosis factor (TNF-α), and interleukin 6 (IL-6) are known to be involved in the inflammation pathogenesis through various cellular and molecular pathways. Phytochemicals are reported to modulate inflammation by inhibiting pro-inflammatory enzymes [36,37]. Therefore, this section will focus on the effect of phenolic extracts from sorghum grains on inhibiting inflammation in vitro and in vivo.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

“…The increase in the secretion of TNF-α and IL-6 of RAW 264.7 macrophages infected by the bacteria Legionella pneumophila was observed after the treatment of polyphenol extracts of sorghum (PI570481) (0.625 and 1.25 mg/mL) [39]. The mRNA expressions of IL-6 and IL-β of RAW 264.7 macrophage cells were significantly inhibited by the soluble phenolic extracts of the sorghum variety (Tong Za 117) at 300 to 500 mg/mL and 50 to 500 mg/mL, respectively, though a non-toxic mechanism [37].…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

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Phenolic Compounds in Whole Grain Sorghum and Their Health Benefits

Wang

Zhao

2021

Foods

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Sorghum grain (Sorghum bicolor L. Moench) is a staple food grown across the globe, and is mainly cultivated in the semi-arid regions of Africa and Asia. Recently, sorghum grain is increasingly utilized for human consumption, due to the gluten-free nature and potential phenolic-induced health benefits. Sorghum grain is rich in bioactive phenolic compounds, such as ferulic acid, gallic acid, vanillic acid, luteolin, and apigenin, 3-deoxyanthocyanidins (3-DXA), which are known to provide many health benefits, including antioxidant, anti-inflammatory, anti-proliferative, anti-diabetic, and anti-atherogenic activities. Given an increasing trend of sorghum consumption for humans, this article reviews the content and profile of phenolics in sorghum. It covers aspects of their health benefits and explores their mechanisms of action. The impact of thermal processing, such as boiling, steaming, roasting, and extrusion on sorghum phenolics is also discussed. Compelling data suggest the biological functions of sorghum phenolics, however, further investigations appear warrant to clarify the gap in the current research, and identify promising research topics in future.

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Section: Anti-inflammatory Effectmentioning

confidence: 99%

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Phenolic Compounds in Whole Grain Sorghum and Their Health Benefits

Wang

Zhao

2021

Foods

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“…Several in vitro studies have reported on the strong antioxidative and anti-inflammatory capacity of sorghum compounds [ 5 , 6 ]. Moreover, sorghum consumption may be beneficial for the prevention of cancer.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate

Lee

et al. 2021

IJMS

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Colon cancer (CC) is considered a high-risk cancer in developed countries. Its etiology is correlated with a high consumption of red meat and low consumption of plant-based foods, including whole grains. Sorghum bran is rich in polyphenols. This study aimed to determine whether different high-phenolic sorghum brans suppress tumor formation in a genetic CC rodent model and elucidate mechanisms. Tissue culture experiments used colorectal cancer cell lines SW480, HCT-116 and Caco-2 and measured protein expression, and protein activity. The animal model used in this study was APC Min+/mouse model combined with dextram sodium sulfate. High phenolic sorghum bran extract treatment resulted in the inhibition of proliferation and induced apoptosis in CC cell lines. Treatment with high phenolic sorghum bran extracts repressed TNF-α-stimulated NF-κB transactivation and IGF-1-stimulated PI3K/AKT pathway via the downregulation of β-catenin transactivation. Furthermore, high-phenolic sorghum bran extracts activated AMPK and autophagy. Feeding with high-phenolic sorghum bran for 6 weeks significantly suppressed tumor formation in an APC Min/+ dextran sodium sulfate promoted CC mouse model. Our data demonstrates the potential application of high-phenolic sorghum bran as a functional food for the prevention of CC.

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“…Speciality grain sorghum is reported to contain bioactive compounds such as phenolic compounds, including phenolic acids (benzoic and cinnamic acids), flavonoids (3-deoxyanthocyanidins), condensed tannins (proanthocyanidins, flavin-3-ols), lignin and stilbenes produced through phenylpropanoid pathway [9,16] possessing anti-microbial activity, and anti-inflammatory and anticancer activities [49,50]. Several in-vitro studies have reported on the strong anti-oxidative and anti-inflammatory capacity of sorghum compounds [51,52]. According to the phenolic profile and color, sorghum is broadly classified into five types: white, black, brown, red and yellow [40].…”

Section: Discussionmentioning

confidence: 99%

Large-Scale Non-Targeted Metabolomics Reveals Antioxidant, Nutraceutical and Therapeutic Potentials of Sorghum

et al. 2021

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Sorghum is one of the most important food and feed cereal crops and has been gaining industrial importance in recent years for its biofuel, nutraceutical and antioxidant values. A genetic profile variation study was undertaken for the accumulation of phytochemicals in 61 diverse sorghum accessions differing in their growth habitat and grain color through non-targeted Gas Chromatography–Mass Spectrometry (GC-MS/MS) analysis. Mass Spectrometry–Data Independent AnaLysis (MS-DIAL) and MetaboAnalyst identified 221 metabolites belonging to 27 different phytochemicals. Tropical and temperate sorghums were distinct in their metabolic profiles with minimum overlaps, and 51 different metabolites were crucial in differentiating the two groups. Temperate sorghums had the ability to accumulate more of phenolic acids, phytosterols, flavonoids, carotenoids, and tropical sorghums for stress-related amino acids, sugars and fatty acids. Grain-color-based Partial Least Square–Discriminant Analysis (PLS-DA) analysis identified 94 Variable Importance in Projections (VIP) metabolites containing majority of flavonoids, phenylpropanoids and phytosterols. This study identified two sorghum lines (IS 7748 and IS 14861) with rich amounts of antioxidants (catechins and epicatechins) belonging to the group of condensed tannins that otherwise do not accumulate commonly in sorghum. Out of 13 metabolic pathways identified, flavonoid biosynthesis showed the highest expression. This study provided new opportunities for developing biofortified sorghum with enhanced nutraceutical and therapeutics through molecular breeding and metabolic engineering.

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Triacylglycerols compositions, soluble and bound phenolics of red sorghums, and their radical scavenging and anti-inflammatory activities

Cited by 41 publications

References 38 publications

Phenolic Compounds in Whole Grain Sorghum and Their Health Benefits

Phenolic Compounds in Whole Grain Sorghum and Their Health Benefits

Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate

Large-Scale Non-Targeted Metabolomics Reveals Antioxidant, Nutraceutical and Therapeutic Potentials of Sorghum

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