Abstract:Evaluation of: Herker E, Harris C, Hernandez C et al.: Efficient hepatitis C virus particle formation requires diacyglycerol acyltransferase-1. Nat. Med. 16, 1295–1298 (2010). Two diacylglycerol acyltransferase (DGAT) enzymes catalyze the final step of triglyceride synthesis, with structural, topological and physiological differences. They also contribute to the formation of cytosolic lipid droplets, which have been shown to play an essential role in HCV replication. Selective inhibition or silencing of DGAT1,… Show more
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