2014
DOI: 10.1016/j.yjmcc.2014.04.005
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Abstract: Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have great potential as a cell source for therapeutic applications such as regenerative medicine, disease modeling, drug screening, and toxicity testing. This potential is limited, however, by the immature state of the cardiomyocytes acquired using current protocols. Tri-iodo-L-thyronine (T3) is a growth hormone that is essential for optimal heart growth. In this study, we investigated the effect of T3 on hiPSC-CM maturatio… Show more

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Cited by 352 publications
(343 citation statements)
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“…hESC-CM and hiPS-CM in MM displayed a higher level of sarcomeric organization and increased their contraction stress by 140% and 170% respectively when compared to CMs cultured in BPEL and by 43% and 41% in comparison to CMs in CA. These results are in accordance with previously reported findings that T3 hormone increased contractile maturation in hiPS-CM [33]. Interestingly, both hESC-CM and hiPS-CM in MM generated significantly higher contraction stress than hFetal-CM.…”
Section: Discussionsupporting
confidence: 93%
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“…hESC-CM and hiPS-CM in MM displayed a higher level of sarcomeric organization and increased their contraction stress by 140% and 170% respectively when compared to CMs cultured in BPEL and by 43% and 41% in comparison to CMs in CA. These results are in accordance with previously reported findings that T3 hormone increased contractile maturation in hiPS-CM [33]. Interestingly, both hESC-CM and hiPS-CM in MM generated significantly higher contraction stress than hFetal-CM.…”
Section: Discussionsupporting
confidence: 93%
“…1). Recent studies have shown that T3 thyroid hormone has the potential to stimulate different characteristics of cardiomyocyte maturation [33]. Both hESC-CMs and hiPS-CMs cultured in MM showed an increase of 140% and 170% in contraction stress, respectively, compared to CMs cultured in BPEL or a 43% and 41% increase compared to CMs in CA media on day 33 (hESC-CM -BPEL 0.21 ± 0.07 mN/mm 2 , CA 0.36 ± 0.02 mN/mm 2 , MM 0.52 ± 0.04 mN/mm 2 P < 0.0001) and (hiPS-CM -BPEL 0.18 ± 0.02 mN/mm 2 , CA 0.36 ± 0.02 mN/mm 2 , MM 0.51 ± 0.04 mN/mm 2 P < 0.0001) (Fig.…”
Section: Increase In Hpsc-cm Maturity In Vitromentioning
confidence: 99%
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“…Thus, Yang et al [29] have shown that T3 promotes the modulation of human cardiomyocytes derived from induced pluripotent stem cells.…”
Section: Stimulation Of Regenerationmentioning
confidence: 99%
“…Given that previously undetected cardiac toxicity is one of the leading causes of drug development failure, the problem appears to be significant (Navarrete et al, 2013). Thus, the need for mature ESC/iPSC-CMs is clearly recognized, and many groups have attempted to improve ESC/iPSC-CM maturation by a variety of methods (Kim et al, 2010;Kuppusamy et al, 2015;Nunes et al, 2013;Yang et al, 2014b).…”
Section: Introductionmentioning
confidence: 99%