Trends of chronic lymphocytic leukemia incidence and mortality in the United States: a population-based study over the last four decades

Alabrach, Yousef S; Mahmoud, Amir; Abdelhay, Ali; Mansour, Mohamad Jihad; Adra, Saryia

doi:10.1080/17474086.2023.2243385

Cited by 1 publication

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies of real-world data are subjected to some level of surveillance bias, individuals with increased health-seeking behavior being more likely to have a slowly progressing malignancy detected. However, the spiked sampling activity observed in myelodysplastic syndrome was not observed to the same extent in chronic lymphocytic leukemia or plasma cell diseases although these are just as often slowly progressing and more frequently occurring [35,36]. We therefore deem it unlikely that surveillance bias alone drove the observations presented in this study.…”

Section: Strengths and Limitationsmentioning

confidence: 53%

Blood sampling patterns in primary care change several years before a cancer diagnosis

Christensen,

Grand,

Kriegbaum

et al. 2024

View full text Add to dashboard Cite

BackgroundA sudden increase in blood sample requisitions from primary care physicians may indicate an incentive to investigate certain symptoms further. Patients with slowly progressing malignancies may debut with insidious symptoms and seek medical attention with increasing frequency, which indeed has been demonstrated through different markers of primary care activity in the last 1-2 years prior to a cancer diagnosis [1,2]. However, within hematological malignancies in particular, early signs of slowly progressing or pre-malignant conditions may in fact be detectable several years before the malignant disease is diagnosed [3][4][5]. Identifying early signs of malignancy or pre-malignancy is important in order to increase chances of successful treatment and lower morbidity and mortality [6][7][8]. Even in asymptomatic and otherwise low-risk hematological patients, it has been demonstrated that early detection may enable risk stratification for follow-up of the (pre-)malignant conditions, help provide relevant care and improve early disease detection in the right patients [9]. In this descriptive study we aimed to describe the pre-diagnostic activity in primary care going back 15 years prior to the malignant diagnosis in order to explore if laboratory activity may indicate that early (pre-)malignant conditions register in primary care years before a diagnosis is made. This was done by describing the blood sampling activity patterns in primary care in both cancer patients to-be and controls, looking at both solid tumors and hematological malignancies. The overall aim of the study was to evaluate the potential for earlier diagnosis of certain malignant diseases. Methods PopulationCancer cases consisted of patients in the greater Copenhagen area with a malignant diagnosis registered in the exhaustive LETTER CONTACT Mathilde Egelund Christensen

show abstract

Section: Strengths and Limitationsmentioning

confidence: 53%