Trends in Prescribing of Antiseizure Medications in South Korea: Real-World Evidence for Treated Patients With Epilepsy

Anti-seizure medications and quality of life in person with epilepsy

“…Anxiety and depression are substantially more common in epilepsy patients than in the healthy population, which shows that patients exhibiting symptoms of anxiety and/or depression are not receiving substandard care in the epilepsy management [ 12 , 13 ]. In terms of ASMs, it has also been demonstrated that initial prescription of monotherapy and further addition of newer regimens was more effective in controlling seizures and reduced the seizure frequency significantly in PWE [ 14 , 15 , 16 ]. However, the use of these bi or polyherapy ASMs has been found to cause drug resistance and showed adverse effects in PWE.…”

Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019

“…Other older ASMs such as carbamazepine, phenytoin, and phenobarbital were less prescribed irrespective of the population with epilepsy. Recent population-based studies also showed reduced prescriptions of enzyme-inducing ASMs [6,29,30]. These findings might reflect the reported concerns that enzyme-inducing ASMs may worsen comorbid coronary and cerebrovascular disease by inducing hyperlipidemia and accelerating the metabolism of concomitant drugs used for their treatment [31].…”

Topiramate dosage optimization for effective antiseizure management via population pharmacokinetic modeling

“…In recent years, the utilization of topiramate monotherapy has become less common in South Korea due to the development of next‐generation ASMs. 31 , 32 However, topiramate remains a highly effective option when used as an add‐on therapy. Our study highlights the importance of using lower doses than previously suggested.…”