Trends in Nanotechnology for Practical Applications

Rashid, Mohammad; Ahmad, Qazi Zaid; Tajuddin, Tajuddin

doi:10.1016/b978-0-12-814029-1.00011-9

Cited by 16 publications

(13 citation statements)

References 90 publications

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“…Moreover, these actions may result in numerous adjacent side effects due to mutilation caused to the immediate healthy tissues, interruptions in the analysis (Baram-Pinto et al, 2010). Treating the cancerous cells by employed Nano-range drug deliveries method plays a significant part in disabling the restrictions of predictable action methodologies by offering instantaneous diagnostics (Rashid and Ahmad, 2019). Therefore, a substantial volume of study focuses on the nanocarrier growth of AuNPs and their possible sustainable applications in cancerous biology.…”

Section: Gold Nanoparticles Cancer Antibacterial and Hiv Treatmentmentioning

confidence: 99%

Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

et al. 2020

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Herein, the role of metal-based nanoparticles (NPs) in biomedical analysis and the treatment of critical deceases been highlighted. In the world of nanotechnology, noble elements such as the gold/silver/palladium (Au/Ag/Pd) NPs are the most promising emerging trend to design bioengineering materials that could to be employed as modern diagnostic tools and devices to combat serious diseases. NPs are considered a powerful and advanced chemical tool to diagnose and to cure critical ailments such as HIV, cancer, and other types of infectious illnesses. The treatment of cancer is the most significant application of nanotechnology which is based on premature tumor detection and analysis of cancer cells through Nano-devices. The fascinating characteristic properties of NPs-such as high surface area, high surface Plasmon resonance, multi-functionalization, highly stable nature, and easy processing-make them more prolific for nanotechnology. In this review article, the multifunctional roles of Au/Ag/Pd NPs in the field of medical science, the physicochemical toxicity dependent properties, and the interaction mechanism is highlighted. Due to the cytotoxicity of Ag/Au/Pd NPs, the conclusion and future remarks emphasize the need for further research to minimize the toxicity of NPs in the bio-medicinal field.

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Section: Gold Nanoparticles Cancer Antibacterial and Hiv Treatmentmentioning

confidence: 99%

Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

et al. 2020

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“…It is arguable that with more widespread adoption of in vitro modelling platforms for conducting transport and biocompatability studies, this number is set to increase [14]. At present, considerable precedence is given to their application in cancer nanotherapy [9,16] as this is arguably the most ubiquitous indication for most rationally designed nanoplatforms. A snapshot of the of privately and publicly funded clinical studies conducted around the world is given in Table 3 (www.clinicaltrials.gov accessed on 19/09/21).…”

Section: Inorganic Nanotheranostic Clinical Pipelinementioning

confidence: 99%

“…Nanomedicines have constituted one of the major breakthroughs in such novel drug delivery efforts, and has been the focus of intensified efforts in the past twenty years. Although they are not the "magic bullet" purported by Nobel laureate Paul Ehrlich as substances that seek out specific disease causing agents, they have led to a notable advancement particularly in the field of oncological diagnostics and chemotherapy [9]. One of their fundamental limitations is in delivery efficiency, as mean nanoparticle delivery efficiency is in the region of 0.7% to 5% for a single intravenous administered dose, which primarily relies on passive targeting approaches [10].…”

Section: Introductionmentioning

confidence: 99%

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders

Lynch

Gobbo

2021

Nanomaterials

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Nanotheranostics constitute a novel drug delivery system approach to improving systemic, brain-targeted delivery of diagnostic imaging agents and pharmacological moieties in one rational carrier platform. While there have been notable successes in this field, currently, the clinical translation of such delivery systems for the treatment of neurological disorders has been limited by the inadequacy of correlating in vitro and in vivo data on blood–brain barrier (BBB) permeation and biocompatibility of nanomaterials. This review aims to identify the most contemporary non-invasive approaches for BBB crossing using nanotheranostics as a novel drug delivery strategy and current non-animal-based models for assessing the safety and efficiency of such formulations. This review will also address current and future directions of select in vitro models for reducing the cumbersome and laborious mandate for testing exclusively in animals. It is hoped these non-animal-based modelling approaches will facilitate researchers in optimising promising multifunctional nanocarriers with a view to accelerating clinical testing and authorisation applications. By rational design and appropriate selection of characterised and validated models, ranging from monolayer cell cultures to organ-on-chip microfluidics, promising nanotheranostic particles with modular and rational design can be screened in high-throughput models with robust predictive power. Thus, this article serves to highlight abbreviated research and development possibilities with clinical translational relevance for developing novel nanomaterial-based neuropharmaceuticals for therapy in CNS disorders. By generating predictive data for prospective nanomedicines using validated in vitro models for supporting clinical applications in lieu of requiring extensive use of in vivo animal models that have notable limitations, it is hoped that there will be a burgeoning in the nanotherapy of CNS disorders by virtue of accelerated lead identification through screening, optimisation through rational design for brain-targeted delivery across the BBB and clinical testing and approval using fewer animals. Additionally, by using models with tissue of human origin, reproducible therapeutically relevant nanomedicine delivery and individualised therapy can be realised.

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“…The scientific community has identified theranostics as a part of personalized medicine; theranostics refers to precision medicine in which drugs are selected individually for each patient, according to the predicted response thereof or to the risk of a disease [1,2]. The essence of the phenomenon does not really change, and theranostics, as an original trend, is a combination of early diagnosis and therapy.…”

Section: Approaches To Theranostics Current Trends and Toolsmentioning

confidence: 99%

The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

et al. 2021

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This review presents the main patterns of synthesis for theranostics platforms. We examine various approaches to the interpretation of theranostics, statistics of publications drawn from the PubMed database, and the solid-state and medicinal chemistry methods used for the formation of nanotheranostic objects. We highlight and analyze chemical methods for the modification of nanoparticles, synthesis of spacers with functional end-groups, and the immobilization of medicinal substances and fluorophores. An overview of the modern solutions applied in various fields of medicine is provided, along with an outline of specific examples and an analysis of modern trends and development areas of theranostics as a part of personalized medicine.

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Trends in Nanotechnology for Practical Applications

Cited by 16 publications

References 90 publications

Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders

The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

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