Trends in incidence of oesophageal and stomach cancer subtypes in Europe

Steevens, Jessie; Botterweck, A.A.M.; Dirx, M.J.M.; Brandt, Piet A. van den; Schouten, Leo J.

doi:10.1097/meg.0b013e32832ca091

Cited by 141 publications

(153 citation statements)

References 28 publications

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“…The incidence of upper-third gastric cancer including cancer of the gastroesophageal junction has been increasing steadily in Western countries, even though the incidence of gastric cancer is on the decline [1][2][3]. A similar trend has been observed in Japan and in Eastern countries in recent decades [4,5].…”

Section: Introductionmentioning

confidence: 57%

Proximal gastrectomy with exclusion of no. 3b lesser curvature lymph node dissection could be indicated for patients with advanced upper-third gastric cancer

et al. 2016

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Background Proximal gastrectomy has been introduced for early gastric cancer located in the upper third of the stomach, but expansion of its indication to advanced tumors has not been generally accepted in terms of lesser curvature lymph node dissection. Methods We reviewed the medical records of 385 patients with tumors in the upper third of the stomach, and the incidence of metastasis and the therapeutic index related to the proximal (no. 3a) and distal (no. 3b) lymph nodes of the lesser curvature were analyzed and compared with those of tumors in the middle third (n = 1093) and lower third (n = 922) of the stomach. Results The no. 3a rate of metastasis from advanced tumors in the upper third of the stomach was significantly higher than that from tumors in the middle third or lower third of the stomach. The no. 3b metastasis rate did not show any significant differences between the three locations, but the therapeutic index of no. 3b lymph nodes in the upper third of the stomach (1.7) was far lower than that in the middle third (7.1) or lower third (7.0). Further, the rate of metastasis from tumors with the distal border ending in the upper third of the stomach (2.2 %) was significantly (P \ 0.0001) lower than that from tumors located in the upper third of the stomach but extending to the middle third (19.6 %), as well as from tumors located in middle third (17.1 %) or lower third (19.6 %), with the therapeutic index being only 1.1. The four no.-3b-positive tumors all measured more than 40 mm, and included one T3 tumor and three T4 tumors. Conclusion Proximal gastrectomy with exclusion of no. 3b lymphadenectomy could be indicated for at least T2 tumors measuring less than 40 mm localized in the upper third of the stomach.

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Section: Introductionmentioning

confidence: 57%

Proximal gastrectomy with exclusion of no. 3b lesser curvature lymph node dissection could be indicated for patients with advanced upper-third gastric cancer

et al. 2016

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“…In addition to environmental factors, genetic factors also play an important role in GC etiology, and previous reports suggest that combinations of genetic and/or epigenetic changes in oncogenic and tumor suppressor pathways may drive GC [10][11][12]. Based on cancer epidemiology, pathological characteristics, and tumor location, GCs can be categorized into three distinct malignancies arising in the same organ: (1) proximal nondiffuse cancers of the cardia and gastroesophageal junction, which are rapidly increasing in incidence in the Western Hemisphere and are related to lifestyle factors, obesity, and chronic gastric acid reflux; (2) diffuse-type GC derived from poorly differentiated or signet-ring cell adenocarcinoma; and (3) distal nondiffuse intestinal-type GC, linked to precursor lesions arising from atrophic gastritis and chronic inflammation related to Helicobacter pylori [11,[13][14][15]. Genetic background according to ethnicity may be related to differences in the histological and anatomical subtypes of GC; therefore, analysis taking into account GC subtypes is necessary to clarify molecular mechanisms of GC carcinogenesis and progression.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer

et al. 2014

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Background Patients with advanced gastric cancer (GC) have an adverse prognosis even after curative resection. Development of novel diagnostic and therapeutic approaches for GC is urgently required. Methods The expression and methylation status of DENN/MADD domain-containing protein 2D (DEN-ND2D), a member of the membrane trafficking proteins, were evaluated in 12 GC cell lines and 112 pairs of surgical specimens. Subgroup analysis based on tumor differentiation, location, and morphology was also performed. Expression and distribution of DENND2D protein were determined by immunohistochemistry. Results The majority of GC cell lines (75 %) and tissues (79 %) showed reduced expression of DENND2D mRNA compared with noncancerous gastric tissues. GC tissues showed a significantly lower mean expression level of mRNA and a higher frequency of promoter hypermethylation of DENND2D than corresponding noncancerous tissues. No significant differences in DENND2D mRNA expression and methylation status were found between GC subtypes categorized by tumor differentiation, location, and morphology. The expression patterns of DENND2D protein were confirmed to be consistent with those of DENND2D mRNA. Downregulation of DENND2D mRNA in GC tissues was significantly associated with factors related to more advanced GC and subsequent adverse prognosis. Among 72 patients who underwent R0 resection, downregulation of DENND2D mRNA in GC tissues was an independent prognostic factor and associated with early recurrence. Conclusions Our results suggested that DENND2D is a putative tumor suppressor gene regulated by promoter hypermethylation in GC. Downregulation of DENND2D can serve as a novel tumor biomarker to predict progression and early recurrence of all types of GC.

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“…Recent studies have reported a continuing rise in the incidence of adenocarcinoma of the gastroesophageal junction (GEJ) despite a decline in the overall incidence of gastric carcinoma in Western countries [1,2]. Adenocarcinoma of the GEJ is defined as carcinoma centered within 5 cm of the anatomic GEJ, which is further classified into three distinct entities (types I, II, and III) according to the anatomic location of the tumor center [3,4].…”

Section: Introductionmentioning

confidence: 99%

Pattern of abdominal nodal spread and optimal abdominal lymphadenectomy for advanced Siewert type II adenocarcinoma of the cardia: results of a multicenter study

et al. 2012

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Background It remains uncertain whether radical lymphadenectomy combined with total gastrectomy actually contributes to long-term survival for Siewert type II adenocarcinoma of the cardia. We identified the pattern of abdominal nodal spread in advanced type II adenocarcinoma and defined the optimal extent of abdominal lymphadenectomy. Methods Eighty-six patients undergoing R0 total gastrectomy for advanced type II adenocarcinoma were identified from the gastric cancer database of 4,884 patients. Prognostic factors were investigated by multivariate analysis. The therapeutic value of lymph node dissection for each station was estimated by multiplying the incidence of were considered not beneficial to dissect, whereas there were substantial therapeutic benefits to dissecting the perigastric nodes of the upper half of the stomach in positions 1-3 and the second-tier nodes in positions 7 and 11. Conclusions Limited lymphadenectomy attained by proximal gastrectomy might suffice as an alternative to extended lymphadenectomy with total gastrectomy for obtaining On behalf

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Trends in incidence of oesophageal and stomach cancer subtypes in Europe

Cited by 141 publications

References 28 publications

Proximal gastrectomy with exclusion of no. 3b lesser curvature lymph node dissection could be indicated for patients with advanced upper-third gastric cancer

Proximal gastrectomy with exclusion of no. 3b lesser curvature lymph node dissection could be indicated for patients with advanced upper-third gastric cancer

Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer

Pattern of abdominal nodal spread and optimal abdominal lymphadenectomy for advanced Siewert type II adenocarcinoma of the cardia: results of a multicenter study

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