Trends in eczema, rhinitis, and rye grass sensitization in a longitudinal asthma cohort

Tai, Andrew; Tran, Haily; Roberts, Mary Flynn; Clarke, Nadeene; Wilson, John W.; Robertson, Colin F.

doi:10.1016/j.anai.2014.03.005

Cited by 7 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, there has been an increase in atopy worldwide over the past few decades, and second, there is a documented increase in atopy during childhood and adolescence. 12 , 13 , 35 In addition, two-thirds of the families enrolled in this study had at least one parent with a history of atopy and those participants with early sensitization were less likely to withdraw from the 24-year follow-up. This may reflect some selection bias among those recruited and retained for long-term follow-up due to their increased interest in the study.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Owens¹,

Laing²,

Zhang³

et al. 2018

JAA

View full text Add to dashboard Cite

PurposeThe aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.Participants and methodsThis prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45% to 72% at follow-up assessments. Asthma diagnosis was based on physician diagnosis of asthma and symptoms/medications in the previous 12 months. Allergic sensitization was defined by the positive skin prick test. Hay fever and eczema were based on a questionnaire.ResultsThe prevalence of allergic sensitization rose from 19% (n=33) at 1 year of age to 71% (n=77) at 24 years of age. The rate of asthma halved from 25% at 6 years of age to 12%–15% between 11 and 24 years of age, but the prevalence of allergic sensitization among those with asthma doubled from 50% at 6 years of age to 100% at 24 years of age. Hay fever rates rose throughout childhood from 7% at 6 years of age to 44% at 24 years of age, while the prevalence of eczema reduced from 25% at 6 years of age to 16% at 24 years of age. Parental atopy doubled the odds of asthma in their offspring by 24 years of age (odds ratio [OR]= 2.63, 95% CI 1.1–6.2, p=0.029). In all, 74% of those with asthma at 24 years of age also reported hay fever. The relationship between eczema and asthma was only significant up to 11 years of age, and the relationship between hay fever and asthma was stronger in adolescence and early adulthood than in early childhood.ConclusionPatterns of atopic disorders vary throughout childhood. Although the prevalence of allergic sensitization and hay fever rose throughout childhood and the prevalence of asthma reduced, the strength of their relationship with asthma increased with age.

show abstract

Section: Discussionmentioning

confidence: 98%

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Owens¹,

Laing²,

Zhang³

et al. 2018

JAA

View full text Add to dashboard Cite

show abstract

“…18 Airflow limitation and air trapping with incomplete reversal after bronchodilator administration are other prominent features 19 that may worsen during adolescence 20 and increase the risk of chronic obstructive pulmonary disease in later adulthood. 21, 22 …”

Section: Clinical Asthma Phenotypes In Sarpmentioning

confidence: 99%

Severe Asthma Phenotypes — How Should They Guide Evaluation and Treatment?

Fitzpatrick

Moore

2017

The Journal of Allergy and Clinical Immunology: In Practice

109

View full text Add to dashboard Cite

Although patients with “severe” asthma tend to be characterized by ongoing symptoms and airway inflammation despite treatment with high doses of inhaled and systemic corticosteroids, there is increasing recognition of marked phenotypic heterogeneity within affected patients. While “precision medicine” approaches for patients with severe asthma are needed, there are many hurdles that must be overcome in daily practice. The National Heart, Lung and Blood Institute's Severe Asthma Research Program (SARP) has been at the forefront of phenotype discovery in severe asthma for the past decade. SARP, along with other international groups, have described clinical severe asthma phenotypes in both adults and children that can be evaluated in the clinical setting. While these clinical phenotypes provide a good “starting point” for addressing disease heterogeneity in severe asthma in everyday practice, more efforts are needed to understand how these phenotypes relate to underlying disease mechanisms and pharmacological treatment responses. This review highlights the clinical asthma phenotypes identified to date, their associations with underlying endotypes and potential biomarkers, and remaining knowledge gaps that must be addressed before precision medicine can become a reality for patients with severe asthma.

show abstract

“…5 Adolescence is known to be an important period of potential change in the body's response to allergens when eczema decreases in prevalence. 26 Age at first-presentation of eczema in the TAHS cohort, as assessed at age of 53 years using the ISAAC questionnaire, seemed to follow a bimodal distribution in which new onset eczema peaked during infancy and around middle age. This bimodal distribution of eczema across the lifespan could potentially be limited by recall bias, with participants questioned during their sixth decade of life.…”

Section: Discussionmentioning

confidence: 92%

“…This is consistent with previous reports of a lower prevalence of eczema in male adults and older age groups, 7,9 and a lack of association of eczema with sex in children and adolescents 5 . Adolescence is known to be an important period of potential change in the body's response to allergens when eczema decreases in prevalence 26 …”

Section: Discussionmentioning

confidence: 99%