Trends in Depression and Antidepressant Prescribing in Children and Adolescents: A Cohort Study in The Health Improvement Network (THIN)

Wijlaars, Linda; Nazareth, Irwin; Petersen, Irene

doi:10.1371/journal.pone.0033181

Cited by 84 publications

(108 citation statements)

References 29 publications

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“…According to current literature, the human being involved in care, in particular the team of health professionals is not adequately trained to deal with child depression [222]. Thus, further research is necessary focused on the development of programs designed to prepare health professionals to deal directly or indirectly with childhood depression in the family and clinical environment, enabling them to detect and properly treat this disease, minimizing its destructive effects.…”

Section: Resultsmentioning

confidence: 99%

“…Antidepressants are commonly prescribed to children and adolescents for depression, anxiety, and a variety of other disorder [221,222]. The efficacy of pharmacologic treatment in pediatric depressive disorders remains unclear, as the majority of placebo-controlled randomized controlled trials (RCTs) of antidepressant medication do not show a significant benefit of medication over placebo [13,223].…”

Section: Treatmentmentioning

confidence: 99%

“…Selective serotonin reuptake inhibitors (SSRIs), first introduced in the late 1980s, were prescribed to children for depression on the basis of effectiveness data from trials on adult psychiatric disorders coupled with other trial data demonstrating the ineffectiveness of tricyclic antidepressants [222,[225][226][227][228].…”

Section: Treatmentmentioning

confidence: 99%

“…The emergence of suicidal thinking and behavior, or unusual changes in behavior should be monitored during the early phases (generally the first 1-2 months) of antidepressant treatment, especially in children, adolescents and young adults between 18 to 24 years old [210]. Fluoxetine is licensed for major depressive disorder in children over eight years [224] and is the only drug currently licensed to treat depression in children in the United Kingdom as its benefits were deemed greater than its risks [222]. Youth who are adherent to fluoxetine treatment have lower symptom severity over the course of treatment [231].…”

Section: Treatmentmentioning

confidence: 99%

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Childhood Depression As Emerging Public Health Problem: A Systematic Review

Pimentel¹,

Júnior²,

Júnior³

et al. 2015

Int Arch Med

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As an important problem of public health, the childhood depression deserves special attention, in which the serious and long term consequences of the disease weigh to the childhood development. Taking this in consideration, the present study was based in the following research question: which practical contribution the actual scientific literature about childhood depression has to offer to clinicians and researchers? The aim of the present study was to evaluate the actual evidence concerning the different aspects (etiology/risk factors, diagnosis, treatment, prognostic and prevention) of childhood depression, with the purpose to systematize such evidences and to contribute with the knowledge about the problem. In way to reach this aim, it was performed a systematic review of articles about childhood depression, in the period from January first of 2010 to January 16 of 2014, in the databases PubMED, MEDLINE and SciELO. In the research, the following terms were used: "depression" (MeSH), "child" (MeSH) and "childhood depression" (Keyword). Of the 860 found studies, 76 met the eligibility criteria. The found studies covered a wide variety of aspects related to childhood depression, as diagnosis, treatment, prevention and prognostic. The actual scientific literature about the childhood depression converges to, directly or not, highlight the negative impacts of the depression disorders to the life quality of the children. Unfortunately, the found studies show that the childhood depression is a disorder that develops most commonly in a poverty and vulnerability scenery, where the individual and familiar necessities concerning the childhood depression are not always taken in consideration. In this context, this review demonstrates that the depression started in

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Section: Resultsmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Childhood Depression As Emerging Public Health Problem: A Systematic Review

Pimentel¹,

Júnior²,

Júnior³

et al. 2015

Int Arch Med

View full text Add to dashboard Cite

show abstract

“…In relation to pharmaceutical interventions, fluoxetine has gained approval for the treatment of childhood depression, although the use of other serotonin-reuptake inhibitors (SSRIs) and tricyclic antidepressants are often used (Wijlaars et al, 2012). Unfortunately, efficacy rates are disappointing with findings from several meta-analyses suggesting they provide only minimal-to-moderate benefit for the treatment of paediatric depression (Henry et al, 2012;Hetrick et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A review of nutrient treatments for paediatric depression

Lopresti

2015

Journal of Affective Disorders

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Paediatric depression is estimated to affect 15 to 20% of youths prior to adulthood and is associated with significant social, educational and physical impairment. Current treatments comprise moderately efficacious psychological therapies and pharmaceutical antidepressants. However, nutritional therapies are also available and are regularly sought by people with depressive illnesses and parents of depressed youths. In this narrative review, studies examining the antidepressant effects of individual nutritional supplements in child and adolescent populations are appraised.Epidemiological studies examining the relationship between nutritional status and paediatric depression, or depressive symptoms are also reviewed. Nutrients covered in this article include: omega-3 polyunsaturated fatty acids, s-adenosylmethionine, vitamin C, vitamin D, zinc, iron and Bvitamins. Although several of these nutrients present as promising treatments for paediatric depression, there is a lack of high-quality studies examining the antidepressant effects of all the aforementioned ingredients. Before nutritional treatments are accepted as validated treatments for paediatric depression, further high-quality studies are required.

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