Trends in colorectal cancer incidence and related lifestyle risk factors in 15⿿49-year-olds in Canada, 1969⿿2010

Patel, Parth; De, Prithwish

doi:10.1016/j.canep.2016.03.009

Cited by 115 publications

(96 citation statements)

References 44 publications

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“…This large study based on a single, national population registry describes detailed epidemiological changes in colorectal cancer incidence in a young adult population. The finding that the incidence of colorectal cancer is increasing rapidly in young adults supports recent findings from other nations with a high human development index. Rapid increases were observed in adults aged 20–39 years, which appear to be driven by increases in the rate of distal tumours.…”

Section: Discussionsupporting

confidence: 86%

“…A US study, using Surveillance, Epidemiology, and End Results data, revealed a doubling in the incidence rate of both colonic and rectal cancers among patients aged between 20 and 54 years since 1974. Similar findings have been demonstrated in cohorts from Canada, Australia, New Zealand and, most recently, Europe, suggesting that the underlying risk of colorectal cancer is increasing in young people.…”

Section: Introductionsupporting

confidence: 83%

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Demographic trends in the incidence of young-onset colorectal cancer: a population-based study

Chambers

Dixon

White

et al. 2020

British Journal of Surgery

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Background Evidence is emerging that the incidence of colorectal cancer is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Methods A population‐based cohort study was carried out including all adults aged 20–49 years diagnosed with colorectal cancer in England between 1974 and 2015. Data were extracted from the National Cancer Registration and Analysis Service database using ICD‐9/10 codes for colorectal cancer. Temporal trends in age‐specific incidence rates according to sex, anatomical subsite, index of multiple deprivation quintile and geographical region were analysed using Joinpoint regression. Results A total of 56 134 new diagnoses of colorectal cancer were analysed. The most sustained increase in incidence rate was in the group aged 20–29 years, which was mainly driven by a rise in distal tumours. The magnitude of incident rate increases was similar in both sexes and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence occurred in the southern regions of England. Conclusion Colorectal cancer should no longer be considered a disease of older people. Changes in incidence rates should be used to inform future screening policy, preventative strategies and research agendas, as well as increasing public understanding that younger people need to be aware of the symptoms of colorectal cancer.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionsupporting

confidence: 83%

Demographic trends in the incidence of young-onset colorectal cancer: a population-based study

Chambers

Dixon

White

et al. 2020

British Journal of Surgery

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“…The possible reasons for a rising incidence of rectal cancer in younger patients remain speculative and further epidemiological studies are required to clarify these. It may be partially attributable to the steep rise in obesity and reduction in physical activity, although this does not fully explain the increased incidence, as these lifestyle factors are also common in older groups. This study and results from North American databases suggest that potentially similar trends could be present in other developed areas of the world.…”

Section: Discussionmentioning

confidence: 66%

Population-based study demonstrating an increase in colorectal cancer in young patients

Gandhi

Davidson

Hall

et al. 2017

British Journal of Surgery

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“…The rise in early onset CRC occurred in all racial/ethnic groups except APIs (although the increase was not statistically significant in AI/ANs, likely because of small numbers); was largest among NHWs (2.3% per year from 2000 to 2013) (Table 7); and has also been reported in other high-income countries, including Norway, 64 Australia, 65 and Canada. 66 Although causes for this increase have yet to be elucidated, factors thought to have contributed include increased prevalence of excess body weight, as well as changes in lifestyle patterns that precipitated the obesity epidemic, including unhealthy dietary patterns and a sedentary lifestyle. 61,[67][68][69][70]…”

Section: Temporal Trendsmentioning

confidence: 99%

Colorectal cancer statistics, 2017

Siegel

Miller

Fedewa

et al. 2017

CA A Cancer J Clinicians

3,795

2,870

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Colorectal cancer (CRC) is one of the most common malignancies in the United States. Every 3 years, the American Cancer Society provides an update of CRC incidence, survival, and mortality rates and trends. Incidence data through 2013 were provided by the Surveillance, Epidemiology, and End Results program, the National Program of Cancer Registries, and the North American Association of Central Cancer Registries. Mortality data through 2014 were provided by the National Center for Health Statistics. CRC incidence rates are highest in Alaska Natives and blacks and lowest in Asian/Pacific Islanders, and they are 30% to 40% higher in men than in women. Recent temporal patterns are generally similar by race and sex, but differ by age. Between 2000 and 2013, incidence rates in adults aged ≥50 years declined by 32%, with the drop largest for distal tumors in people aged ≥65 years (incidence rate ratio [IRR], 0.50; 95% confidence interval [95% CI], 0.48-0.52) and smallest for rectal tumors in ages 50 to 64 years (male IRR, 0.91; 95% CI, 0.85-0.96; female IRR, 1.00; 95% CI, 0.93-1.08). Overall CRC incidence in individuals ages ≥50 years declined from 2009 to 2013 in every state except Arkansas, with the decrease exceeding 5% annually in 7 states; however, rectal tumor incidence in those ages 50 to 64 years was stable in most states. Among adults aged <50 years, CRC incidence rates increased by 22% from 2000 to 2013, driven solely by tumors in the distal colon (IRR, 1.24; 95% CI, 1.13-1.35) and rectum (IRR, 1.22; 95% CI, 1.13-1.31). Similar to incidence patterns, CRC death rates decreased by 34% among individuals aged ≥50 years during 2000 through 2014, but increased by 13% in those aged <50 years. Progress against CRC can be accelerated by increasing initiation of screening at age 50 years (average risk) or earlier (eg, family history of CRC/advanced adenomas) and eliminating disparities in high-quality treatment. In addition, research is needed to elucidate causes for increasing CRC in young adults. CA Cancer J Clin 2017. © 2017 American Cancer Society. CA Cancer J Clin 2017;67:177-193. © 2017 American Cancer Society.

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Trends in colorectal cancer incidence and related lifestyle risk factors in 15⿿49-year-olds in Canada, 1969⿿2010

Cited by 115 publications

References 44 publications

Demographic trends in the incidence of young-onset colorectal cancer: a population-based study

Demographic trends in the incidence of young-onset colorectal cancer: a population-based study

Population-based study demonstrating an increase in colorectal cancer in young patients

Colorectal cancer statistics, 2017

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