Treatment with β-cyclodextrin of natural Cryptosporidium parvum infections in lambs under field conditions

Castro‐Hermida, J. A.; Quílez, Joaquín; López-Bernad, F.; Sánchez-Acedo, Caridad; Freire-Santos, F; Ares-Mazás, Elvira

doi:10.1016/s0020-7519(01)00220-x

Cited by 25 publications

(16 citation statements)

References 14 publications

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“…Other drugs that have been tested with good therapeutic results against lamb cryptosporidiosis are paromomycin (Viu et al. , 2000) and β ‐cyclodextrin (Castro‐Hermida et al. , 2001, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Concerning other drugs, the preventive treatment of lambs with β ‐cyclodextrin delayed the onset of diarrhoea and reduced its duration (Castro‐Hermida et al. , 2001).…”

Section: Discussionmentioning

confidence: 99%

“…, 2005), paromomycin (aminosidin) (Viu et al. , 2000) and β ‐cyclodextrin (Castro‐Hermida et al. , 2001, 2002) have been tested against cryptosporidiosis with various results.…”

Section: Introductionmentioning

confidence: 99%

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Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial

Giadinis

Papadopoulos

Panousis

et al. 2007

Vet Pharm & Therapeutics

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This study aimed to investigate the effects of halofuginone lactate (100 mug/kg BW) on treatment and prevention of cryptosporidiosis in lambs. It consisted of three field trials. The first trial was designed to assess the efficacy of halofuginone in treating lamb diarrhoea caused by cryptosporidiosis, and in preventing the disease, using two schemes; halofuginone given for seven and for three consecutive days respectively. Halofuginone was effective in the treatment of diarrhoea caused by cryptosporidiosis (P < 0.01). In addition, halofuginone administered as a 7-day treatment was significantly (P < 0.05) more effective than a 3-day treatment in preventing diarrhoea in the infected flocks. The second trial was designed to evaluate the preventive effect of halofuginone, which was administered for 7 days in lambs infected with cryptosporidiosis, on diarrhoea incidence, oocyst shedding and body weight gain. Halofuginone significantly (P < 0.01) reduced the diarrhoea incidence, the time of oocyst shedding and the mean intensity of shedding, but did not affect body weight gain. The third trial was designed to examine the ability of halofuginone to reduce the death rate in flocks with cryptosporidiosis. Halofuginone treatment was effective in preventing and in reducing the death rate of cryptosporidiosis in these flocks.

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Section: Discussionmentioning

confidence: 99%

“…Concerning other drugs, the preventive treatment of lambs with β ‐cyclodextrin delayed the onset of diarrhoea and reduced its duration (Castro‐Hermida et al. , 2001).…”

Section: Discussionmentioning

confidence: 99%

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Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial

Giadinis

Papadopoulos

Panousis

et al. 2007

Vet Pharm & Therapeutics

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“…There is no specific cure for cryptosporidiosis in goats, several drugs have been analyzed for their cryptosporicidal activities, which includes -Cyclodextrin (Castro-Hermida et al, 2001), -Cyclodextrin (Castro-Hermida et al, 2004, Decoquinate (Ferre et al, 2005), Nitazoxanide (Viel et al, 2007), Tilmicosin (paraud et al, 2010), Halofuginone lactate (Giadinis et al, 2007(Giadinis et al, , 2008 and Paromomycin sulphate (Johnson et al, 2000;Viu et al, 2000).…”

Section: Treatment Of Caprine Cryptosporidiosismentioning

confidence: 99%

Cryptosporidiosis in Goats: a Review

Paul¹

2014

Adv. Anim. Vet. Sci.

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“…The www.elsevier.com/locate/vetpar Available online at www.sciencedirect.com Veterinary Parasitology 155 (2008) [308][309][310][311][312][313] presence of a C. parvum sporozoite surface lectin specific to galactose-N-acetylgalactosamine (Gal-Gal-NAc), and which may mediate attachment of sporozoites to host cells, has been demonstrated (Chen and LaRusso, 1999). The many drugs tested to date, such as halofuginone lactate, paromomycin and cyclodextrins (Mancassola et al, 1995;Chartier et al, 1996Chartier et al, , 1999Viu et al, 2000;Castro-Hermida et al, 2001, 2004 have shown only partial effectiveness in the treatment and prophylaxis of cryptosporidiosis in neonatal lambs and goat kids. Moreover, cryptosporidiosis is difficult to control because of the resistance of the oocysts to environmental conditions and to disinfectants, including sodium hypochlorite, ammonia, chlorine, hydrogen peroxide, glutaraldehyde and formaldehyde (Korich et al, 1990;Castro-Hermida et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs

Castro-Hermida

García-Presedo

González-Warleta

et al. 2008

Veterinary Parasitology

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The efficacy of the anti-inflammatory drug Bobel-24 against experimental infection by Cryptosporidium parvum was evaluated in neonatal lambs. The animals were treated by oral administration of the drug at 50 or 500 mg/kg of body weight. The prophylactic/therapeutic treatment was started 4 h before inoculation of the lambs with oocysts and was continued for eight consecutive days. The therapeutic treatment was initiated at the onset of diarrhoea, after confirmation of infection, and was continued for six consecutive days. Infection was monitored by daily examination of faecal samples from the first day until 30 days post-inoculation. The criteria considered in evaluating development of the infection and the drug activity were: oocyst shedding, presence of diarrhoea and weight gain at 15 and 30 days post-inoculation. Bobel-24 was effective as a prophylactic/therapeutic treatment at the lowest dose (50 mg/kg of body weight); in the group treated with this dose of drug there was a longer prepatent period, a shorter patent period and a lower intensity of oocyst excretion than in the untreated control group, and the differences were all statistically significant (P<0.05). Moreover, one animal did not excrete oocysts, and two lambs had diarrhoea, for only 1 and 2 days. In the group treated with the higher dose of the drug, the diarrhoea lasted for a significantly shorter period (P<0.05) than in the untreated group.

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Treatment with β-cyclodextrin of natural Cryptosporidium parvum infections in lambs under field conditions

Cited by 25 publications

References 14 publications

Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial

Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial

Cryptosporidiosis in Goats: a Review

Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs

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