Treatment with Unsaponifiable Extracts of Avocado and Soybean Increases TGF-.BETA.1 and TGF-.BETA.2 Levels in Canine Joint Fluid

Altınel, Levent; Saritaş, Zülfikar Kadir; Köse, Kamil Çağrı; Pamuk, Kamuran; Aksoy, Yusuf; Serteser, Mustafa

doi:10.1620/tjem.211.181

Cited by 40 publications

(29 citation statements)

References 18 publications

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“…TGF-beta is expressed by chondrocytes and osteoblasts and is present in cartilage matrix. [28] ASU treatment caused an increase in TGF-beta1 and TGF-beta2 levels in the joint fluid when compared to controls. [28] Similarly, administration of Semecarpus anacardium (SA) nut extract brings back the altered antioxidant defense components to near normal levels.…”

Section: Nutraceuticalsmentioning

confidence: 86%

“…[28] ASU treatment caused an increase in TGF-beta1 and TGF-beta2 levels in the joint fluid when compared to controls. [28] Similarly, administration of Semecarpus anacardium (SA) nut extract brings back the altered antioxidant defense components to near normal levels. It exerts antiarthritic effect by retarding lipid peroxidation and causing a modulation in cellular antioxidant defense system.…”

Section: Nutraceuticalsmentioning

confidence: 86%

“…[27] Avocado and soya un-saponifiables (ASU) are plant extracts used as a slow-acting antiarthritic agent. [28] ASU stimulate the synthesis of matrix components by chondrocytes, probably by increasing the production of transforming growth factorbeta (TGF-beta). TGF-beta is expressed by chondrocytes and osteoblasts and is present in cartilage matrix.…”

Section: Nutraceuticalsmentioning

confidence: 99%

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Upadhyay

2016

IJGP

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The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

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Section: Nutraceuticalsmentioning

confidence: 86%

Section: Nutraceuticalsmentioning

confidence: 86%

Section: Nutraceuticalsmentioning

confidence: 99%

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Untitled

Upadhyay

2016

IJGP

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“…In chondrocytes, production of the extracellular matrix is stimulated, such as type II collagen and proteoglycans. Although a study indicates that chondrocytes increase TGF- β1 and TGF- β2 levels in knee joint in dogs, its effect on full-thickness articular cartilage lesions is not revealed in clinics [45]. …”

Section: Discussionmentioning

confidence: 99%

Are We Using Slow-Acting Symptomatic Chondroprotective Drugs Conscious Enough?

Gümüştaş

Öznam

Mutlu

et al. 2017

TOORTHJ

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Background:Osteochondral injuries constitute an entity that is widespread and can be seen in patients of all ages. Actual treatment modalities aim to relieve pain, obtain full range of movement of the joint, and improve the quality of life. There are many slow-acting chondroprotective agents prevalently used in the United States that are classified as nutritional support but not as medicines . This study presents the importance of clinical adverse effect profiles as well as the pharmacological mechanism of action and application of combinations of drugs that are widely prescribed and not subjected to control.Methods:Electronic databases were searched with keywords about the chondroprotective drugs without any language restriction. Evaluations of the descriptive statistics were represented via Microsoft Office Excel 2010 lists in the form of a mean±standard deviation or frequency (%). The first evaluation showed that 1502 studies were potentially relevant. Following exclusion of the 1277 studies which were not clinical, full versions of the remaining 225 studies were subjected to further evaluation. No controlled, blinded, randomized and/or comparative studies met the inclusion criteria of the study, and no studies evaluated the comparative clinical results of the hyaluronan of different molecular weights.Results:The findings of this study concluded that especially when prescribing drugs with ingredients like GS and CS, many patients’ pre-existing conditions must be considered, such as whether the patient has a glucose intolerance or not. Additionally, mineral toxication should be considered since the drugs contain minerals, and after the application of injected hyaluronan, complications should be considered.Conclusion:Clinical, controlled and comparative studies about the use of chondroprotective drugs must be performed to define the benefits of these drugs, if any, in order to determine the most suitable time for operative intervention.

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“…122 Avocado and soy unsaponifiables have in vitro effects suggesting they may be helpful in managing DJD. 123,124 A placebo-controlled canine in vivo trial using avocado and soy unsaponifiables in dogs with experimentally induced DJD showed decreased severity of histologic lesions in treated dogs 123 ; though heterogeneous, results from human trials suggest a possible clinical benefit. 125 …”

Section: Other Nutraceuticalsmentioning

confidence: 99%