Current Opinion in Hematology volume 20, issue 5, P430-436 2013 DOI: 10.1097/moh.0b013e328363c170 View full text
Shari Ghanny, Mark Crowther

Abstract: nOACs are an acceptable alternative to VKAs in certain situations - these are at least as effective as warfarin for secondary prevention of VTE and for prevention of stroke and systemic embolism in patients with atrial fibrillation. These compare favorably with warfarin with respect to their rate of fatal and major bleeding. However, special attention should be given when using these drugs in certain patient populations, in particular in patients with renal insufficiency, those receiving additional antithrombo…

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