“…The intact SHR is characterized by typical behavioral, electrophysiological, and biochemical abnormalities -which are also evident in epileptic rats -such as attention deficit, impulsiveness, deficient sustained attention, and monoamine deficits in the frontal cortex and hippocampus, suggesting that this strain might be used also as a relevant model of ADHD comorbidity (Tchekalarova, 2014). In addition, we recently demonstrated that long-term treatment with melatonin for KA-induced epileptogenesis produces different effects in Wistar rats and SHRs; the finding supported the hypothesis that 21 the underlying mechanisms of behavioral comorbidities in epilepsy differ in these two rat strains (Tchekalarova et al, 2013;Petkova et al, 2014). Indeed, while seizure frequency in epileptic SHRs remained significantly decreased even after discontinuation of melatonin, in…”