Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

“…A recent study has demonstrated that cannabidiol was able to reverse cognitive deficits in an animal model of memory impairment induced by a global systemic insult, such as sepsis (Cassol-Jr et al 2010). In this study the authors report that cannabidiol also reduced sepsis-induced oxidative stress.…”

“…Recent studies have shown that cannabidiol may recover cognitive function in animals submitted to sepsis (Cassol-Jr et al 2010) and to hepatic encephalopathy (Avraham et al 2010). In humans, preliminary results suggest that cannabidiol can have beneficial effects in the treatment of Parkinson's disorder (Zuardi et al 2009) and a double-blind, placebo-controlled trial is currently underway to evaluate this possibility.…”

Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage

“…The reduction of fear-related behaviors evoked by the prey/ predator paradigm also suggests some panicolytic properties [45]. CBD improves performance in numerous animal models of cognitive impairments [30,[46][47][48]. It acts as an antidepressant in animal models of depression and decreases compulsive behaviors in rodents [35,49].…”

Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

“…While the link between anxiety decrease and CBD use has been examined in several pre-clinical and clinical studies, the safety of the CBD doses is still uncertain. Despite the well-known issue about anxiolytic properties of low-intermediary CBD doses, several studies have supported the use of a higher CBD dose as a protective substance against memory deficits induced by THC, inflammatory illness, and other memory-disruptive conditions (Cassol-Jr et al, 2010;Soares et al, 2010;Barichello et al, 2012). On this basis, the use of CBD-rich strains of cannabis has been encouraged, mainly through other strategies of memory assessments that are not aversive (Morgan et al, 2010;Mechoulam and Parker, 2013;Wright et al, 2013).…”

“…Endocannabinoids are released during stressful conditions, and CB1 receptor agonism impairs the acquisition of contextual fear (Marsicano et al, 2002;Hohmann and Suplita, 2006). Acute and chronic administration of CBD and the use of different doses reveal a variety of responses, especially in avoidance tasks (Soares et al, 2010;Cassol-Jr et al, 2010;Barichello et al, 2012;Fagherazzi et al, 2012). In rodents, CBD has a demonstrated therapeutic potential for specific cognitive impairments associated with Alzheimer's disease, probably through enhancement of endocannabinoid-mediated actions (Cheng et al, 2014).…”