Treatment with Benzoyl Peroxide of Ulcers on Legs Within Lesions of Necrobiosis Lipoidica Diabeticorum

Abstract

A lotion of 20% benzoyl peroxide was applied to ulcers on legs from necrobiosis lipoidica diabeticorum. The ulcers healed rapidly and uneventfully, leaving firm, yellow scars. The efficacy and simplicity of use of topical benzoyl peroxide therapy is discussed.

Chronic Balanitis with Palisading Granuloma: An Atypical Genital Localization of Necrobiosis lipoidica Responsive to Pentoxifylline

“…Several treatments have been reported as useful in NL, such as dipyridamole or aspirin [22] or the association of both these drugs [23], intralesional heparin [24], triamcino lone acetonide [25], benzoyl peroxide [26], prostaglandin E, [27] or surgical excision [28]. Two cases that were suc cessfully treated with pentoxifylline have been reported recently [5,6], The exact mode of action of this drug is unknown.…”

Necrobiosis lipoidica diabeticorum: A case-based review of literature

“…The application of benzoyl peroxide to ulcerating NLD has also been reported to be beneficial. [57] Oral chloroquine, which has immunosuppressive and anti-inflammatory properties, improved the inflammatory element of a plaque of NLD on the shin of a non-diabetic woman, possibly via inhibition of macrophage migration, inhibition of prostaglandin synthesis or inhibition of platelet aggregation. [58] Durupt et al .…”

Le benzoyl peroxyde dans le traitement des ulcères de jambe

“…Plusieurs publications récentes rapportent les effets favorables du BPO à 20% sur la cicatrisation des ulcères de jambe [1,6,7,15], des ulcérations de nécrobiose lipoïdique [4], des escarres de décubitus [11,12], du pyoderma gangrenosum [13] et des plaies consécutives à la chimiochirurgie [10].…”

“…Celui-ci exerce un effet détersif sur l'ulcère et stimule la granulation [1,4,6,8,15]. Colman et al [1] ont biopsié des ulcères traités au BPO et ont observé une violente réaction à corps étranger avec une infiltration massive de cellules géantes.…”