Sean S. Davies, Chris Bodine, Elena Matafonova, Brooke G. Pantazides, Nathalie Bernoud-Hubac, Fiona E. Harrison, Sandra J. Olson, Thomas J. Montine, Venkataraman Amarnath, L. Jackson Roberts
Both inflammation and oxidative injury are features of Alzheimer’s disease (AD), but the contribution of these intertwined phenomena to the loss of working memory in this disease is unclear. We tested the hypothesis that highly reactive γ-ketoaldehydes that are formed both by non-enzymatic free radical catalyzed lipid peroxidation and by cyclooxygenases may be causally linked to the development of memory impairment in AD. We found that levels of γ-ketoaldehyde protein adducts were increased in the hippocampus…
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