Treatment Results of Gamma Knife Radiosurgery for Central Neurocytoma: Report of a Japanese Multi-Institutional Cooperative Study

Yamanaka, Kazuhiro; Iwai, Yoshiyasu; Shuto, Takashi; Kida, Yoshihisa; Sato, Mitsuya; Hayashi, Motohiro; Kondo, Takeshi; Hirai, Hisao; Hori, Rentaro; Kubo, Kenji; Mori, Hisae; Nagano, Osamu; Serizawa, Toru

doi:10.1016/j.wneu.2016.03.016

Cited by 25 publications

(36 citation statements)

References 29 publications

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“…The current systematic analysis updates the findings of Park and includes several additional case series published since then for a total of 150 patients [50515253]. To our knowledge, this study represents the largest and most current review of CN patients treated with SRS.…”

Section: Introductionmentioning

confidence: 62%

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Bui

Lagman

Chung

et al. 2017

Brain Tumor Res Treat

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Central neurocytoma (CN) typically presents as an intraventricular mass causing obstructive hydrocephalus. The first line of treatment is surgical resection with adjuvant conventional radiotherapy. Stereotactic radiosurgery (SRS) was proposed as an alternative therapy for CN because of its lower risk profile. The objective of this systematic analysis is to assess the efficacy of SRS for CN. A systematic analysis for CN treated with SRS was conducted in PubMed. Baseline patient characteristics and outcomes data were extracted. Heterogeneity and publication bias were also assessed. Univariate and multivariate linear regressions were used to test for correlations to the primary outcome: local control (LC). The estimated cumulative rate of LC was 92.2% (95% confidence interval: 86.5-95.7%, p<0.001). Mean follow-up time was 62.4 months (range 3-149 months). Heterogeneity and publication bias were insignificant. The univariate linear regression models for both mean tumor volume and mean dose were significantly correlated with improved LC (p<0.001). Our data suggests that SRS may be an effective and safe therapy for CN. However, the rarity of CN still limits the efficacy of a quantitative analysis. Future multi-institutional, randomized trials of CN patients should be considered to further elucidate this therapy.

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Section: Introductionmentioning

confidence: 62%

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Bui

Lagman

Chung

et al. 2017

Brain Tumor Res Treat

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“…Surgery was the primary initial treatment for CN [ 23 – 25 ], but whether complete resection surgery correlates significantly with overall survival was still disputed [ 8 , 24 , 26 , 27 ]. Meanwhile, radiosurgery was also reported by some small sample studies to perform nice effect and little complications to CNs in the past several years [ 28 – 31 ]. Conventional radiotherapy was mainly applied for the management of residual or recurrent CNs [ 32 , 33 ], but its effect to overall survival was still full of controversial [ 8 , 24 , 34 – 36 ], and the radiation-induced toxicity was also hard to be ignored for the long-time clinical course [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic factors of brain central neurocytoma

et al. 2016

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Background & AimsThis study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).MethodsCN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN.ResultsCN tended to be borderline malignant and single lesion. Compared with other brain tumor (NCN), Patients with CN (CNs) were more likely to be female, young, and non-white race. Surgery was the primary treatment of CN. Univariate and Multivariate analysis indicated tumor number and surgery were both independent prognostic factors of CN (P < 0.05). Unifocal CNs had a lower mortality risk than multifocal ones (HR 0.167, 95% CI 0.052-0.537), surgery significantly reduced the death risk of CNs (HR 0.284, 95% CI 0.088-0.921).ConclusionsCN tend to be borderline malignant, single lesion, operated on. Most CNs are female and younger. single lesion and surgery are the independent positive prognostic factors of CN.

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“…Whether radiotherapy should be used after central neurocytoma surgery remains controversial. Some reports suggest that patients should be treated with postoperative radiotherapy to prevent and treat residual tumor recurrence [18][19][20][21]. In this group, 5 patients (23.8%) received radiotherapy after the rst operation.…”

Section: Discussionmentioning

confidence: 99%

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Zhang¹,

Yu²,

Hao³

et al. 2020

Preprint

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Background: Central neurocytoma is a rare intracranial tumor. Due to the limited number of reported cases, the treatment strategy for central neurocytomas, especially large central neurocytomas, remains controversial. This paper discusses our clinical experience in the treatment of large central neurocytomas.Methods: A retrospective analysis of 29 patients with intraventricular central neurocytomas diagnosed and treated by the same surgeon between April 2012 and September 2019 at the Neurosurgery Departments of Beijing Tiantan Hospital and Hainan General Hospital was performed. The clinical characteristics, treatment plans and prognoses of these patients were reviewed.Results: Among the 29 patients, the average age of onset was 31.93 (17-61) years, and the average maximum tumor diameter was 54.17 ± 15.62 mm. Twenty-three patients (79.3%) had an average maximum diameter greater than 50 mm. Twenty-seven patients (93.1%) underwent transcortical tumor resection. Twenty-seven patients (93.1%) underwent gross total tumor resection. Five patients (17.2%) received radiotherapy after the first operation, and 3 patients (10.3%) had tumor recurrence. None of the patients died.Conclusions: Surgical resection via transcortical fistulotomy is a reliable approach for removal of large central neurocytomas in the ventricle. Patients should be closely observed postoperatively, and MRI of the head should be performed regularly. If a tumor shows progression, then radiotherapy should be considered.

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Treatment Results of Gamma Knife Radiosurgery for Central Neurocytoma: Report of a Japanese Multi-Institutional Cooperative Study

Cited by 25 publications

References 29 publications

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Clinical characteristics and prognostic factors of brain central neurocytoma

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

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