Treatment outcomes in patients with signet ring cell carcinoma of the colorectum

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

“…There are 3759 English literatures in original search, after exclusion and screening, 28 English literatures (Cusack et al, 1996;Sun et al, 1996;Wu et al, 1996;Enriquez et al, 1998;Cerottini et al, 1999;Consorti et al, 2000;Nozoe et al, 2000;Kanemitsu et al, 2003;Chen et al, 2004;Du et al, 2004;Papadopoulos et al, 2004;Kang et al, 2005;You et al, 2006;Grillo-Ruggieri et al, 2007;Hill et al, 2007;Lee et al, 2007;Farhat et al, 2008;Pande et al, 2008;Catalano et al, 2009;Min et al, 2009;Song et al, 2009;Xie et al, 2009;Sultan et al, 2010;Catalano et al, 2011;Jivapaisarnpong et al, 2011;Hyngstrom et al, 2012;Langner et al, 2012;Yamaguchi et al, 2012) and 2 Chinese literatures (Songqing et al, 2002;Miao et al, 2005) meet the requirements. In the 30 literatures, 21 literatures can be used for Meta analysis of the relationship of mucinous adenocarcinoma and TNM staging, including 444489 cases, in which mucinous adenocarcinoma were 45050 cases, accounting for 10.1% of all cases; 21 literatures can be used for Meta analysis of relationship of mucinous adenocarcinoma and prognosis, including 450804 cases, in which mucinous adenocarcinoma were 45354 cases, accounting for 10.1% of all cases.…”

“…Due to the heterogeneity (I 2 =88%; P<0.001), we removed the large heterogeneity literatures, including Du et al (2004), Hyngstrom et al (2012), Kane mitsu et al (2003), Kang et al (2005), Lee et al (2007), Papadopoulos et al (2004), then the heterogeneity was reduced significantly (I 2 =33%; P=0.1), the analysis results were consistent with previous overall analysis, the HR value was 1.48 (CI: 1.35-1.62; P<0.001), suggesting that the meta-analysis results are accurate and reliable (Figure 2). …”

Primary signet ring cell carcinoma of the colon and rectum

“…The reported frequency varies from 0.3 to 4.6% of all colorectal carcinomas with slight differences between western countries, Asia and Africa (figure 1) [3,[5][6][7][8][9][10][11][12]. The highest incidence of SRCC of the colon and rectum is reported in countries with low overall prevalence of colorectal cancer, such as Tanzania [10].…”

“…However, these data should be interpreted carefully because the majority of epidemiological data on SRCC of the colon and rectum are based on single institution studies [5,6,10], rarely from large population-based studies of colorectal cancer histology [11,12]. The mean age at diagnosis of colorectal SRCC reported in published series ranges from 48 to 70 years old [7,9]. This large difference in age among series is likely due to the bias associated with single institution studies including small number of patients.…”

Correlação de fatores anatomopatológicos com a sobrevida de pacientes operados por adenocarcinoma colorretal

“…Os tumores com alto grau histológico (pouco diferenciados e indiferenciados) apresentam correlação independente com pior prognóstico em alguns estudos [12][13] , porém em outros, não há relação de significância estatística com a sobrevida 14 . O subtipo histológico colóide ou mucinoso representa aproximadamente 17% dos adenocarcinomas e é mais freqüente em pacientes jovens, relacionando-se com maior taxa de recidiva local e pior prognóstico em algumas séries [15][16] . Já outros autores, não encontraram significância prognóstica em pacientes com o mesmo estadiamento tumoral 17 .…”