Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary smear positive and negative tuberculosis patients in Anqing, China: a retrospective study

Wen, Yufeng; Zhang, Zhiping; Li, Xian‐Xiang; Xia, Dan; Ma, Jun; Dong, Yuanyuan; Zhang, Xinwei

doi:10.1186/s12879-018-3019-7

Cited by 50 publications

(65 citation statements)

References 30 publications

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“…TB cases in our study cohort were mostly adult males, a trend similarly observed worldwide [1]. We also found that being males and older age were significantly associated with unsuccessful TB treatment outcomes and all-cause mortality, concurring with findings reported elsewhere [12,32,33]. Urban and rural places of residence, as well as varying levels of education, were well represented with fair distribution among patients in our study cohort.…”

Section: Plos Onesupporting

confidence: 90%

“…Worldwide, studies had investigated on TB treatment outcomes by looking into factors that were associated with unsuccessful treatment outcomes as well as mortality among TB patients [8][9][10][11][12][13]. Important predictive factors reported include patients' sociodemographic characteristics (age, sex, education levels, employment), underlying comorbidities such as diabetes mellitus (DM) and human immunodeficiency virus (HIV) infection as well as TB disease profile/ factors (sputum and radiological findings, site of TB infection, history of previous TB treatment).…”

Section: Introductionmentioning

confidence: 99%

“…Findings from studies investigating on TB treatment outcomes invariably differ according to the local settings of TB patients' population [8][9][10][11][12][13]. It is therefore apt to perform cohort analyses in the local context, from time to time, to monitor the TB treatment outcomes and provide feedback on the national TB control program [3,14].…”

Section: Introductionmentioning

confidence: 99%

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Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study

Tok¹,

Liew²,

Wong³

et al. 2020

PLoS ONE

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smoking, extrapulmonary TB, history of previous TB treatment, advanced chest radiography findings and human immunodeficiency virus (HIV) infection. Factors found associated with all-cause mortality were similar except for nationality (higher among Malaysians) and place of residence (higher among rural dwellers), while smoking and history of previous TB treatment were not found to be associated with all-cause mortality. Conclusions This study identified various sociodemographic characteristics and TB disease-related variables which were associated with unsuccessful TB treatment outcomes and mortality; these can be used to guide measures for risk assessment and stratification of TB patients in future.

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Section: Plos Onesupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study

Tok¹,

Liew²,

Wong³

et al. 2020

PLoS ONE

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“…The multivariate logistic regression revealed that pretreatment weight < 40 kg, older age (> 45 years), and HIV infection independently associated with unsuccessful treatment outcomes. Independent association of older age (> 30 years [28], retreatment and HIV co-infected [26] with unfavorable treatment outcome was also reported by others. Thus, TB patients with pretreatment weight < 40 kg, older age (> 45 years), and HIV infected need special social and economic support, early diagnosis and close monitoring throughout their treatment period in the refugee camps in Ethiopia.…”

Section: Discussionsupporting

confidence: 69%

Tuberculosis (TB) in the Refugee Camps in Ethiopia: Trends of Case Notification, Profile, and Treatment Outcomes, 2014 to 2017

Legesse

Admenur

Gebregzabher

et al. 2020

Preprint

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Background: Severity of TB increases in refugee populations. Monitoring TB case notification and treatment outcomes are essential to evaluate the effectiveness of TB programs. This study aimed to determine trends in TB case notification and treatment outcomes and explore factors associated with unsuccessful treatment outcome in refugee camps in Ethiopia. Methods: This retrospective cohort study was conducted from October 2018-June 2019. Demographic and clinical data of all TB cases registered from 2014 to 2017 in 25 refugee camps located in seven refugee areas (Shire, Afar, Gambella, Asossa, Mizam, Jijiga, and Dollo Ado) were extracted using pre-tested data extraction format. Multivariate logistic regression was performed to calculate odds ratios and 95% confidence intervals for factors associated with unsuccessful outcomes.Results. A total of 1553 TB cases, mean age 27.7 years, were registered (2014-2017). Of these notified cases 54.7% were men, 27.7% children (< 15 years), 71.2% pulmonary TB (PTB), 27.8% Extra-PTB (EPTB) and 98.3% new and relapse. From 2014 to 2017: there was consistent increase in the number of notified TB cases (138 to 588 cases), in the percentage of EPTB (23.2% to 32.7%), bacteriologically confirmed pulmonary new and relapse (43.8% to 64.8%), and contribution of children to total TB cases (18.8% to 30.1%) and to EPTB (40.6% to 65.1%). Treatment success rates for all TB cases remained lower at 72.7%-79.4% (on average 11.7% were not evaluated, 8.0% lost to follow-up (LTFU), 4.8% died, and 0.5% failed). Unsuccessful treatment was significantly associated with pretreatment weight below 40 Kg, age over 45 years, and being HIV positive.Conclusions: This study has provided valuable evidences that can help to improve the TB programs. There was increased trend in number of notified TB cases, and in proportion of EPTB, childhood TB, and bacteriologically confirmed pulmonary new and relapse cases. Treatment success rate (2014-2017) was far below global target (90%), and “not evaluated” and LTFU treatment outcomes were higher, which need to be improved. Special socio-economic support and monitoring is required for patients with pretreatment weight below 40 Kg, age over 45 years and HIV positives who at risk for unsuccessful treatment.

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“…In contrary, according to a study done in Nigist Eleni Mohammod General Hospital Hosanna, Ethiopia; those patients having smear-positive Pulmonary TB were more likely to had poor treatment outcomes compared with those patients having extra-pulmonary TB [7]. But, the other studies done in other parts of Ethiopia [15,20] and China [27] reported as there is no significant difference between treatment success rate and type of TB. According to studies conducted at Jinka General Hospital [21], Afar [28] and another study done by Kefale et al at Southwest Ethiopia [29]; TB/HIV co-infection was found to be a predictor for unsuccessful treatment outcome, which is similar to the present study.…”

Section: Discussionmentioning

confidence: 93%

Tuberculosis treatment outcome among patients treated in public primary healthcare facility, Addis Ababa, Ethiopia: a retrospective study

2020

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Background: Despite the availability of effective drugs, tuberculosis remains a major public health problem that predominantly affects low-and middle-income countries. This study aimed to assess tuberculosis treatment outcomes among patients treated at one of the primary health care levels in Addis Ababa, Ethiopia. Methods: An institutional-based retrospective cross-sectional study was conducted at a tuberculosis clinic in public primary healthcare facility. The study populations were all patients with tuberculosis who had been completed their treatment course in the center from July 2014 to July 2018. After getting Ethical clearance and permission from the health center, trained data collectors working in the center were recruited. The collected data were checked for completeness every day by the principal investigators. Data were edited, cleaned, and analyzed using SPSS version 25. Descriptive statistics were used to summarize the data while multinomial logistic regression was employed to explore associations among variables of interest, and p < 0.05 was considered as statistically significant. Results: A total of 352 patients with tuberculosis were included for the study with a median age of 25 years which ranged from 1 to79 year. Most (36.4%) participants were in the age group of 15 to 24 years. The majority (38.8%) of patients had extrapulmonary tuberculosis, 11.9% of them were HIV positive and only two had family history of tuberculosis. Regarding treatment outcome, 238(67.6%) completed the treatment, 95(27%) cured and the rest were unsuccessful treatment outcomes 19(5.4%) either died, defaulted or treatment failed. The odds ratio for cured in relation to unsuccessful treatment outcome was found to be significantly higher in HIV negative patients (AOR = 6.1; 95%CI 2.1-13.9) compared with those patients tested positive for HIV. While patients with smearpositive pulmonary tuberculosis (AOR = 10.5, 95% CI 5.36-16.31) were significantly associated with the odds of having complete treatment cure as compared to patients with extrapulmonary tuberculosis. Similarly being HIV positive and extrapulmonary tuberculosis were predicting factors for unsuccessful treatment compared with their counterparts. Conclusions: The finding of the present study showed that successful tuberculosis treatment outcome was found to be optimal.

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Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary smear positive and negative tuberculosis patients in Anqing, China: a retrospective study

Cited by 50 publications

References 30 publications

Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study

Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study

Tuberculosis (TB) in the Refugee Camps in Ethiopia: Trends of Case Notification, Profile, and Treatment Outcomes, 2014 to 2017

Tuberculosis treatment outcome among patients treated in public primary healthcare facility, Addis Ababa, Ethiopia: a retrospective study

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