Treatment Options: Biological Basis of Regenerative Endodontic Procedures

Hargreaves, Kenneth M.; Diogenes, Aníbal; Teixeira, Fabrício B.

doi:10.1016/j.joen.2012.11.025

Cited by 319 publications

(297 citation statements)

References 97 publications

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“…A potential disadvantage when using TAP is the possibility of tooth discoloration 4,12,13) due to minocycline 4,13) . The double antibiotic paste (DAP), that excludes minocycline, has also been successfully used for RET 14,15) . Other concerns associated with intracanal use of antibiotics are: fear of promoting antibiotic resistance, risk of allergic reaction 12) and biocompatibility of the medicament 16) .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy of several intracanal medicaments for endodontic therapy

et al. 2017

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The antibacterial efficacy of intracanal medicaments for 2 and 7 days, in open apex root canals contaminated with Enterococcus faecalis biofilms was compared. One hundred and thirty-eight standardized uniradicular human roots were inoculated with E. faecalis. Colony forming units (CFU) were recorded before and after medication. Samples were divided in two (2/7 days), and subdivided (n=8/group): triple antibiotic paste (TAP); double antibiotic paste (DAP); dental base paste (DBP), consisting of calcium hydroxide, propylene glycol and calcium carbonate; DBP+0.2% chlorhexidine (CHX); DBP+0.2% cetrimide (CTR); DBP+0.2% CHX+0.2% CTR; 2.5% sodium hypochlorite (NaOCl); and distilled water. At both periods TAP, DAP, DBP+0.2% CHX, DBP+0.2% CTR and DBP+0.2% CHX+0.2% CTR exhibited no growth (NG) of E. faecalis. Distilled water and 2.5% NaOCl obtained the lowest CFU reduction. No growth with DBP was reached only at 7 days. CHX and/or CTR pastes were as effective as DAP and TAP. A 2-day period provided an effective disinfection.

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Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy of several intracanal medicaments for endodontic therapy

et al. 2017

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“…Dental pulpal stem cells (DPSC) under the appropriate stimuli have also demonstrated exceptional multipotency, including adipocytes, myocytes, neurons and osteoblasts [9] . In terms of application, DPSC have seen increasing use in the field of endodontics as regenerative treatment of pulpal necrosis of the permanent dentition, with studies indicating dentin-like tissue formation both in vitro and in mandibular defects [10] . Periodontal ligament stem cells (PDLSC) also demonstrates multipotency, with the most notable being osteogenesis and cementogenesis [29,30] .…”

Section: Resultsmentioning

confidence: 99%

“…Under different stimuli, DPSC can differentiate into adipocytes, myocytes, neurons and osteoblasts among other cell types [9] . With their capacity to differentiate into osteoblasts, DPSC have seen increasing use in the field of endodontics as they promise a more reliable, regenerative tissue approach for treatment of pulpal necrosis of the permanent dentition [10] . Thus far, DPSC have been shown to contribute to dentinlike tissue formation in vitro and bone repair in mandibular defects [11] , showing promise in the field of hard-tissue engineering both for bone and dentin.…”

Section: Background and Applicationsmentioning

confidence: 99%

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Nguyen

James

et al. 2015

International Journal of Orthopaedics

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Tissue specific mesenchymal stem cells are of great scientific interest across diverse fields in stem cell biology and medicine. Sources of mesenchymal stem cells (MSC) in the craniomaxillofacial skeleton are numerous and are of significant interest to craniofacial and oral surgeons, among other medical and dental specialties. Mesenchymal stem cells are defined by their characteristic cell surface marker expression, multipotentiality and ability for self-renewal. Bone marrow derived MSC (BMSC) are most commonly studied, but are of low abundance in the craniomaxillofacial (CMF) skeleton. Alternative CMF sources of MSC are diverse and include dental pulpal stem cells (DPSC), periodontal ligament stem cells (PDLSC), suture-derived mesenchymal stromal cells (SMC), gingival mesenchymal stem cells (GMSC)and adipose-derived MSC (ASC). This brief review will introduce various MSC sources derived from the head and neck, along with a discussion of their identity, characteristics and results of preclinical studies in tissue engineering.

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“…Revascularization of the pulp space in a necrotic tooth infected with apical periodontitis was believed to be impossible 2 . Revascularization is an optional treatment for permanent teeth with open apex which examines the maximum capacity of the pulp for dentin apposition and production of a stronger mature root to give more support against forces causing fractures 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the degree of coronal pigmentation in extracted premolars after the application of bi-antibiotic and tri-antibiotic pastes

Mejía

Monterrsa

2015

Joralres

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Abstract:Objective: To compare the degree of pigmentation in coronal extracted premolars after applying bi-antibiotic and tri-antibiotic pastes. Method: Intentional non-probability sampling. A total of 30 healthy premolars which were extracted for orthodontic reasons and met the inclusion criteria were divided into 2 experimental groups and a control group of 10 teeth each. Group I (G1) was treated with bi-antibiotic paste, group II (G2) with tri-antibiotic paste; and group III or control (G3) was treated with saline solution. Two observers previously calibrated took the initial color sample from each tooth by giving them a value corresponding to the shade guide. After access opening and instrumentation, all teeth received the appropriate medication and color records were taken under the same initial light conditions for 30 days after the procedure. The obtained data were compiled into Excel for further descriptive and inferential analysis with SPSS 19.0. ANOVA test was used with a confidence level of 95%. Results: The degree of pigmentation was 1±0.9 in G1, 12.2±1.2 in G2 and 0.9±0.8 in G3. No statistically significant differences were found between G1 and G3 (p=0.8086), but there was between G1 and G2 (p<0.001), and G2 and G3 (p<0.001). Conclusion: The degree of pigmentation with tri-antibiotic paste was higher than the degree of pigmentation with bi-antibiotic paste used as temporary medication. No difference was found between the degree of pigmentation in the group treated with bi-antibiotic and the control group treated with saline solution. Bi-antibiotic paste did not show pigmentation in the crown of the extracted premolars.

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Treatment Options: Biological Basis of Regenerative Endodontic Procedures

Cited by 319 publications

References 97 publications

Antibacterial efficacy of several intracanal medicaments for endodontic therapy

Antibacterial efficacy of several intracanal medicaments for endodontic therapy

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Comparison of the degree of coronal pigmentation in extracted premolars after the application of bi-antibiotic and tri-antibiotic pastes

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