2000
DOI: 10.1001/archderm.136.10.1274-a
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Treatment of Warts With Candida Antigen Injection

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Cited by 54 publications
(60 citation statements)
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“…The therapeutic response to intralesional MMR vaccine in our study was much higher than that reported by Kus et al 17 (29.4%), Clifton et al 18 (47%), King et al 19 (50%), Signore 20 (51%) and Horn et al 21 (53%), slightly higher than that reported by Johnson and Horn 22 (70.9%), similar to that reported by Phillips et al 23 (72%) and slightly lower than that reported by Johnson et al 24 (74%) , Brunk 25 (85%), Gupta et al 26 (88.9%) and Maronn et al 27 (87%). The presence of three synergistic viral antigens in MMR vaccine that could be associated with higher stimulation of the immune system may explain the relatively higher response in our study as compared to most of the related studies which utilize either a single antigen [17][18][19][20][21][22][23][24] or a combination of antigens. 19,22 The exact mechanism of action of intralesional immunotherapy is still obscure.…”
Section: Discussionsupporting
confidence: 68%
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“…The therapeutic response to intralesional MMR vaccine in our study was much higher than that reported by Kus et al 17 (29.4%), Clifton et al 18 (47%), King et al 19 (50%), Signore 20 (51%) and Horn et al 21 (53%), slightly higher than that reported by Johnson and Horn 22 (70.9%), similar to that reported by Phillips et al 23 (72%) and slightly lower than that reported by Johnson et al 24 (74%) , Brunk 25 (85%), Gupta et al 26 (88.9%) and Maronn et al 27 (87%). The presence of three synergistic viral antigens in MMR vaccine that could be associated with higher stimulation of the immune system may explain the relatively higher response in our study as compared to most of the related studies which utilize either a single antigen [17][18][19][20][21][22][23][24] or a combination of antigens. 19,22 The exact mechanism of action of intralesional immunotherapy is still obscure.…”
Section: Discussionsupporting
confidence: 68%
“…A similar observation of absent or low rates of recurrence have also been reported by similar related studies. [23][24][25][26] Intralesional MMR vaccine has shown significant advantages over other treatments. Most of the recently available treatments are painful and need multiple visits.…”
Section: Discussionmentioning
confidence: 99%
“…The stimulated immune system would destroy all warts in the body, sparing patients from local treatment for each individual wart. 7 It has been reported that untreated warts resolve after injection of only one wart with intralesional immunotherapy that induces HPV-directed immunity. 8 Antigens used for intralesional immunotherapy include tuberculin, BCG, mumps, candida and trichophyton and MMR.…”
Section: Discussionmentioning
confidence: 99%
“…The idea of using Candida skin testing reagent as a novel vaccine adjuvant came about from observations that intralesional injections of recall antigens result in common wart regression (48)(49)(50)(51)(52)(53)(54). Traditionally, recall antigens, which typically include a panel derived from Candida, mumps virus, and Trichophyton, were used as a control to indicate intact cell-mediated immunity in patients (48)(49)(50)(51)(52)54).…”
Section: De Novo Immune Stimulationmentioning
confidence: 99%
“…Traditionally, recall antigens, which typically include a panel derived from Candida, mumps virus, and Trichophyton, were used as a control to indicate intact cell-mediated immunity in patients (48)(49)(50)(51)(52)54). These studies suggested that T cells may have a role in wart regression.…”
Section: De Novo Immune Stimulationmentioning
confidence: 99%