Treatment of Vitiligo With Oral and Topical Phenylalanine: 6 Years of Experience

Camacho, F.

doi:10.1001/archderm.135.2.216

Cited by 24 publications

(9 citation statements)

References 4 publications

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“…Phenylalanine is given orally at a dose of 50 mg/kg, 30 min to 1 h before 2–12 J/cm 2 UVA exposure (PheUVA) (43). A large retrospective study was performed on 193 patients who were treated with a combination of topical and oral phenylalanine, followed by midday sun exposure (55). The authors reported an overall improvement rate of 83.1%, with the maximum response on the face.…”

Section: Puva Therapymentioning

confidence: 99%

Photo(chemo)therapy for vitiligo

Pacifico

Leone

2011

Photoderm Photoimm Photomed

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Vitiligo is a common skin disease characterized by loss of normal melanin pigments in the skin and its pathogenesis is still unclear. Treatment modalities include psoralen plus ultraviolet A, narrow-band ultraviolet B (NB UVB) phototherapy, topical and systemic steroids, topical calcineurin inhibitors, topical vitamin D analogues in monotherapy or in association with phototherapy, and surgical treatment. NB UVB (310-315 nm) radiation is now considered as the 'gold standard' for the treatment of diffuse vitiligo, and treatment with two recently introduced UVB sources that emit 308 nm wavelengths, the 308 nm xenon chloride (XeCl) excimer laser and the 308 nm XeCl excimer light, has also been reported to be effective and might be the treatment of choice for localized disease: this treatment modality has been defined as 'targeted phototherapy.'

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Section: Puva Therapymentioning

confidence: 99%

Photo(chemo)therapy for vitiligo

Pacifico

Leone

2011

Photoderm Photoimm Photomed

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“…[112][113][114] Adding topical L-phe to oral L-phe and light therapy is even more beneficial. 115,116 Facial lesions respond best. 115,117 Safety.…”

Section: L-phenylalaninementioning

confidence: 99%

“…115,116 Facial lesions respond best. 115,117 Safety. L-phenylalanine has few significant side effects.…”

Section: L-phenylalaninementioning

confidence: 99%

Vitiligo: A comprehensive overview

Felsten

Alikhan

Petronic‐Rosic

2011

Journal of the American Academy of Dermatology

151

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“…In a non-controlled retrospective survey of 193 patients treated with oral (50 or 100 mg ⁄ kg daily) and topical (10% gel) plus 30 min of sun exposure, a good response with 56.7% repigmentation was achieved; improvement was 90.3% for the face, 42.8% for the trunk, and 37.1% for the limbs (Camacho and Mazuecos, 1999). With the addition of 0.025% clobetasol propionate at night, >75% repigmentation in 68.5% of 70 patients was observed (Camacho and Mazuecos, 2002).…”

Section: Alternate and Adjuvant Therapiesmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

137

121

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SummaryTreatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effective on trunk and limbs and poor on the acral parts of the extremities. Narrow band UVB and psoralens and UVA are the two most important treatments for generalized vitiligo affecting more than 10-20% of the cutaneous surface, and topical corticosteroids, or calcineurin inhibitors are the most valuable treatments for localized vitiligo. Persistence of achieved regimentation is variable and an undefined percentage of patients may have variable recurrence.When vitiligo becomes refractory, surgical methods may improve depigmentation as effectively as with medical therapy; in segmental (unilateral) or long standing, non-segmental (bilateral) stable vitiligo, repigmentation with surgical methods is usually permanent.

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Treatment of Vitiligo With Oral and Topical Phenylalanine: 6 Years of Experience

Cited by 24 publications

References 4 publications

Photo(chemo)therapy for vitiligo

Photo(chemo)therapy for vitiligo

Vitiligo: A comprehensive overview

Update on skin repigmentation therapies in vitiligo

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