Treatment of Trichinosis

Experimental Studies on the Chemotherapy of Rat Lungworm, Angiostrongylus cantonensis, in Rats

“…According to Cuckler (1961), this anthelmintic is particularly effective for roundworms belonging to the orders Strongyloidea, Ascaroidea, and Trichinelloidea. For human helminthic infections, remarkable thera peutic effects have been reported against ascariasis, strongyloidiasis, trichuriasis, trichostrongylosis, trichinosis, enterobiasis, and ancylo stomiasis (Franz, 1963;Huang and Brown 1963;Iwata et al 1963;Stone et al 1964;Salunkhe et al 1964;Spaeth et al 1964;Papasarathorn 1964;Chango 1964;Shah 1965). …”

Experimental Studies on the Chemotherapy of Rat Lungworm, Angiostrongylus cantonensis, in Rats

“…According to Cuckler (1961), this anthelmintic is particularly effective for roundworms belonging to the orders Strongyloidea, Ascaroidea, and Trichinelloidea. For human helminthic infections, remarkable thera peutic effects have been reported against ascariasis, strongyloidiasis, trichuriasis, trichostrongylosis, trichinosis, enterobiasis, and ancylo stomiasis (Franz, 1963;Huang and Brown 1963;Iwata et al 1963;Stone et al 1964;Salunkhe et al 1964;Spaeth et al 1964;Papasarathorn 1964;Chango 1964;Shah 1965). …”

The Effect of Thiabendazole on Pain Threshold

“…Recently, anticonvulsant activity attributed to thiabendazole, was reported by Shashindran (1977). The first trials of thiabendazole in treatment of trichinosis in man resulted either in dramatic clinical improvement and apparent cure (Spaeth et al 1964;Stone et al 1964) or, at least, in a rapid subsidence of the signs and symptoms of the disease (Kean & Hoskins 1964). Clinicians have wondered whether the beneficial effect of thiabendazole in trichinosis could be due in part to non-specific antiinflammatory effects and analgesic properties (Campbell 197 1).…”

Creeping Eruption and Thiabendazole

“…A further justification for this dosage is suggested by the fact that this was the ap¬ parently successful amount used clinically in the third case reported by Stone and Mullins 2 and approximately that used by Mor¬ gan and Moss.5 Moreover, the concentration of thiabendazole in aqueous solution used in experiment A was many fold that which ob¬ tains in the plasma after oral administration as employed here and yet proved innocuous. 4. The time of exposure of the larvae to the chemical ( 12 hours in the case of serum and plasma) may not be as long as that pre¬ vailing in clinical use and thus inadequate.…”

Experimental Studies on the Chemotherapy of Rat Lungworm, Angiostrongylus cantonensis, in Rats

“…According to Cuckler (1961), this anthelmintic is particularly effective for roundworms belonging to the orders Strongyloidea, Ascaroidea, and Trichinelloidea. For human helminthic infections, remarkable thera peutic effects have been reported against ascariasis, strongyloidiasis, trichuriasis, trichostrongylosis, trichinosis, enterobiasis, and ancylo stomiasis (Franz, 1963;Huang and Brown 1963;Iwata et al 1963;Stone et al 1964;Salunkhe et al 1964;Spaeth et al 1964;Papasarathorn 1964;Chango 1964;Shah 1965). …”

The Effect of Thiabendazole on Pain Threshold

“…Recently, anticonvulsant activity attributed to thiabendazole, was reported by Shashindran (1977). The first trials of thiabendazole in treatment of trichinosis in man resulted either in dramatic clinical improvement and apparent cure (Spaeth et al 1964;Stone et al 1964) or, at least, in a rapid subsidence of the signs and symptoms of the disease (Kean & Hoskins 1964). Clinicians have wondered whether the beneficial effect of thiabendazole in trichinosis could be due in part to non-specific antiinflammatory effects and analgesic properties (Campbell 197 1).…”

Creeping Eruption and Thiabendazole

“…A further justification for this dosage is suggested by the fact that this was the ap¬ parently successful amount used clinically in the third case reported by Stone and Mullins 2 and approximately that used by Mor¬ gan and Moss.5 Moreover, the concentration of thiabendazole in aqueous solution used in experiment A was many fold that which ob¬ tains in the plasma after oral administration as employed here and yet proved innocuous. 4. The time of exposure of the larvae to the chemical ( 12 hours in the case of serum and plasma) may not be as long as that pre¬ vailing in clinical use and thus inadequate.…”

Experimental Studies on the Chemotherapy of Rat Lungworm, Angiostrongylus cantonensis, in Rats

“…According to Cuckler (1961), this anthelmintic is particularly effective for roundworms belonging to the orders Strongyloidea, Ascaroidea, and Trichinelloidea. For human helminthic infections, remarkable thera peutic effects have been reported against ascariasis, strongyloidiasis, trichuriasis, trichostrongylosis, trichinosis, enterobiasis, and ancylo stomiasis (Franz, 1963;Huang and Brown 1963;Iwata et al 1963;Stone et al 1964;Salunkhe et al 1964;Spaeth et al 1964;Papasarathorn 1964;Chango 1964;Shah 1965). …”

The Effect of Thiabendazole on Pain Threshold

“…Recently, anticonvulsant activity attributed to thiabendazole, was reported by Shashindran (1977). The first trials of thiabendazole in treatment of trichinosis in man resulted either in dramatic clinical improvement and apparent cure (Spaeth et al 1964;Stone et al 1964) or, at least, in a rapid subsidence of the signs and symptoms of the disease (Kean & Hoskins 1964). Clinicians have wondered whether the beneficial effect of thiabendazole in trichinosis could be due in part to non-specific antiinflammatory effects and analgesic properties (Campbell 197 1).…”

Creeping Eruption and Thiabendazole

“…A further justification for this dosage is suggested by the fact that this was the ap¬ parently successful amount used clinically in the third case reported by Stone and Mullins 2 and approximately that used by Mor¬ gan and Moss.5 Moreover, the concentration of thiabendazole in aqueous solution used in experiment A was many fold that which ob¬ tains in the plasma after oral administration as employed here and yet proved innocuous. 4. The time of exposure of the larvae to the chemical ( 12 hours in the case of serum and plasma) may not be as long as that pre¬ vailing in clinical use and thus inadequate.…”