Treatment of traumatic scars using fat grafts mixed with platelet-rich plasma, and resurfacing of skin with the 1540 nm nonablative laser

Cervelli, Valerio; Nicoli, Fabio; Spallone, Diana; Verardi, Simone; Sorge, Roberto; Nicoli, Marzia; Balzani, Alberto

doi:10.1111/j.1365-2230.2011.04199.x

Cited by 57 publications

(67 citation statements)

References 23 publications

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“…[7][8][9][10][11] PRP releases platelet derived growth factors and regenerates damaged bone and soft tissue. [12][13][14][15] In this aspect, we hypothesized that because of its regenerative properties PRP may reduce the post acne scars when combined with fractional CO2 lasers and minimize the post procedural adverse effects.…”

mentioning

confidence: 99%

Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

et al. 2017

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Background: Many treatments are available for treating post acne scars but optimized treatment does not exist still. Hence, this study was conducted with the aim to evaluate the safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser for treatment of acne scars when used in Indian skin.Methods: Thirty patients attended to the Dermatology OPD were enrolled in the study after meeting inclusion criteria. They underwent split-face therapy. They received ablative fractional carbon dioxide (CO2) laser combined with autologous platelet-rich plasma (PRP) treatment on one half of their face and ablative fractional CO2 laser with intradermal normal saline on the other half. The injections were administered immediately after laser therapy. Each participant received 4 treatments spaced by 1 month and were followed up for a period of 4 months.Results: The outcome among the study subjects were assessed using Goodman and Baron Scale at different time intervals. Significant reduction in acne scars was observed in both PRP injection site and normal saline injection site but better reduction of acne scars was noted at the PRP site. The blinded physician’s assessment and patient satisfaction was better at PRP injected side as compared to the normal saline injected side. The incidence of adverse effects and pain during the procedure was significantly lower in PRP injected side compared normal saline injected side.Conclusions: This study demonstrated that PRP should be considered as an adjuvant therapeutic option for dermatologic procedures such as fractional CO2 laser resurfacing for treatment of post acne scars as it might have additional benefit of reducing the adverse effects such as persistent erythema and edema.

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confidence: 99%

Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

et al. 2017

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“…26,27,43 Autologous fat grafting is also used in combination with other treatments (Table 6). 39,[45][46][47] The levels of evidence were II in five studies, 33,36,39,41,45 III in seven studies, [23][24][25][26]38,42,44 and IV in 14 studies. 22,23,[28][29][30]32,34,35,37,40,43,[46][47][48] Four randomized controlled trials, 33,36,39,45 16 prospective cohort studies, 22,[25][26][27]29,30,32,34,35,37,38,[41]…”

Section: Resultsmentioning

confidence: 99%

The Use of Autologous Fat Grafting for Treatment of Scar Tissue and Scar-Related Conditions

Negenborn

Groen

Smit

et al. 2016

Plastic and Reconstructive Surgery

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Autologous fat grafting is used to improve a variety of symptoms related to scar tissue. This systematic review suggests that autologous fat grafting provides beneficial effects with limited side effects. However, the level of evidence and methodological quality are quite low. Future randomized controlled trials with a methodologically strong design are necessary to confirm the effects of autologous fat grafting on scar tissue and scar-related conditions.

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“…And, one of the most important benefits of PRP in burn therapy is the costeffectiveness of the therapy. The cost of hospital stay is lower (approximately 25% less) than that of patients who did not receive PRP combination treatment [87,88].…”

Section: Prp In Burnsmentioning

confidence: 96%

Platelet-Rich Plasma in Burn Treatment

Ünal¹

2018

Hot Topics in Burn Injuries

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As a general definition, platelet-rich plasma (PRP) is the concentration of autologous human platelets in a small amount of plasma. PRP contains important growth factors deposited in alpha-granules of platelets and plasma proteins such as fibrin, fibronectin, and vitronectin. PRP has been shown to improve wound healing process in acute trauma wounds, incisional wounds, and chronic nonhealing wounds and is a beneficial agent in reconstructions of soft and hard tissue. Furthermore, PRP enhances differentiation of epithelial cell and collagen bundle organization. Effects of growth factors in PRP on wound healing and successful results obtained with PRP treatment in other types of wound lead to the use of PRP for burn treatment.

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Treatment of traumatic scars using fat grafts mixed with platelet-rich plasma, and resurfacing of skin with the 1540 nm nonablative laser

Cited by 57 publications

References 23 publications

Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

The Use of Autologous Fat Grafting for Treatment of Scar Tissue and Scar-Related Conditions

Platelet-Rich Plasma in Burn Treatment

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