Treatment of the Cutaneous Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Silver Nitrate-Impregnated Dressings

Practical guidelines for the management of toxic epidermal necrolysis and Stevens–Johnson syndrome

“…Meticulous wound care is fundamental to improving patient outcomes and minimizing the risks of wound infection or sepsis. Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed re‐epithelialization, minimize pain, and decrease infection rates 9,10 . Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas.…”

“…Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed reepithelialization, minimize pain, and decrease infection rates. 9,10 Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas. We avoid the use of sulfa-containing products because of the risk of systemic sensitization and leukopenia.…”

Practical guidelines for the management of toxic epidermal necrolysis and Stevens–Johnson syndrome

“…Meticulous wound care is fundamental to improving patient outcomes and minimizing the risks of wound infection or sepsis. Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed re‐epithelialization, minimize pain, and decrease infection rates 9,10 . Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas.…”

“…Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed reepithelialization, minimize pain, and decrease infection rates. 9,10 Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas. We avoid the use of sulfa-containing products because of the risk of systemic sensitization and leukopenia.…”

Analysis of Intravenous Immunoglobulin for the Treatment of Toxic Epidermal Necrolysis Using SCORTEN

“…10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

“…The patients were managed with our standard TEN protocol, which included nonstick dressings impregnated with isotonic sodium chloride solution (normal saline) or silver nitrate every 3 to 8 hours and changed every 3 days. 10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

Management of stevens-johnson syndrome-toxic epidermal necrolysis: Looking beyond guidelines!

“…Literature for management of SJS-TEN in children is lacking. However, a recent review[ 102 ] found that IVIg, systemic corticosteroids (prednisolone, methylprednisolone, and dexamethasone),[ 103 ] dressings,[ 104 105 ] surgical debridement, and support treatment alone; were the major treatment modalities. Few children were given ulinastatin, plasmapheresis, G-CSF,[ 106 ] IV pentoxifylline,[ 107 ] skin substitutes,[ 108 ] and cyclosporine.…”

Practical guidelines for the management of toxic epidermal necrolysis and Stevens–Johnson syndrome

“…Meticulous wound care is fundamental to improving patient outcomes and minimizing the risks of wound infection or sepsis. Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed re‐epithelialization, minimize pain, and decrease infection rates 9,10 . Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas.…”

“…Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed reepithelialization, minimize pain, and decrease infection rates. 9,10 Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas. We avoid the use of sulfa-containing products because of the risk of systemic sensitization and leukopenia.…”

Analysis of Intravenous Immunoglobulin for the Treatment of Toxic Epidermal Necrolysis Using SCORTEN

“…10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

“…The patients were managed with our standard TEN protocol, which included nonstick dressings impregnated with isotonic sodium chloride solution (normal saline) or silver nitrate every 3 to 8 hours and changed every 3 days. 10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

Management of stevens-johnson syndrome-toxic epidermal necrolysis: Looking beyond guidelines!

“…Literature for management of SJS-TEN in children is lacking. However, a recent review[ 102 ] found that IVIg, systemic corticosteroids (prednisolone, methylprednisolone, and dexamethasone),[ 103 ] dressings,[ 104 105 ] surgical debridement, and support treatment alone; were the major treatment modalities. Few children were given ulinastatin, plasmapheresis, G-CSF,[ 106 ] IV pentoxifylline,[ 107 ] skin substitutes,[ 108 ] and cyclosporine.…”

Practical guidelines for the management of toxic epidermal necrolysis and Stevens–Johnson syndrome

“…Meticulous wound care is fundamental to improving patient outcomes and minimizing the risks of wound infection or sepsis. Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed re‐epithelialization, minimize pain, and decrease infection rates 9,10 . Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas.…”

“…Wet dressings impregnated with silver nitrate maintain a moist wound environment, speed reepithelialization, minimize pain, and decrease infection rates. 9,10 Hypothermia and hyponatremia are risks associated with the use of these dressings to large body surface areas. We avoid the use of sulfa-containing products because of the risk of systemic sensitization and leukopenia.…”

Analysis of Intravenous Immunoglobulin for the Treatment of Toxic Epidermal Necrolysis Using SCORTEN

“…10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

“…The patients were managed with our standard TEN protocol, which included nonstick dressings impregnated with isotonic sodium chloride solution (normal saline) or silver nitrate every 3 to 8 hours and changed every 3 days. 10 Hematologic, electrolyte, and blood chemistry values was closely monitored. Biopsies and wound cultures were performed on admission.…”

Management of stevens-johnson syndrome-toxic epidermal necrolysis: Looking beyond guidelines!

“…Literature for management of SJS-TEN in children is lacking. However, a recent review[ 102 ] found that IVIg, systemic corticosteroids (prednisolone, methylprednisolone, and dexamethasone),[ 103 ] dressings,[ 104 105 ] surgical debridement, and support treatment alone; were the major treatment modalities. Few children were given ulinastatin, plasmapheresis, G-CSF,[ 106 ] IV pentoxifylline,[ 107 ] skin substitutes,[ 108 ] and cyclosporine.…”