Treatment of superficial onychomycosis with topically applied glutaraldehyde. A preliminary study

Suringa, D. W.

doi:10.1001/archderm.102.2.163

Cited by 11 publications

(1 citation statement)

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“…Miscellaneous drugs have been used in small studies for topical treatment of onychomycosis. A 10% aqueous solution of glutaraldehyde (36) and 1% 5‐fluorouracil in propylene glycol were used (37), although subjects and involvement are poorly described. A solution including salicylate and undecylenic acid in dimethyl sulfoxide (DMSO) was used to treat 32 subjects with onychomycosis caused by different organisms (dermatophyte, nondermatophyte, and yeast) (38).…”

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confidence: 99%

Onychomycosis: diagnosis and topical therapy

Fleckman¹

2002

Dermatol Ther

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Onychomycosis (true fungal infection of the nail plate) is a common malady that may present in several clinical patterns. Because many noninfectious disorders of the nail may masquerade as onychomycosis, the clinical diagnosis must be confirmed by wet mount (potassium hydroxide [KOH] examination), culture, or histology before treatment is begun. Although systemic therapy of onychomycosis with the newer drugs is more effective, the prospect of effective topical therapy is a welcome alternative in many situations. Choices for topical therapy are limited in the United States at this time. As new, improved choices are added to the therapeutic armamentarium, topical therapy my supersede systemic. In addition, the potential for synergism with systemic therapy and for prophylaxis of cleared infections is only now being explored.

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Section: Other Vehiclesmentioning

confidence: 99%

Onychomycosis: diagnosis and topical therapy

Fleckman¹

2002

Dermatol Ther

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Fungal (Onychomycosis) and Other Infections Involving the Nail Apparatus

Hay

Baran

Heneke

2001

Baran and Dawber's Diseases of the Nails and Their Management

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Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures

Ballantyne¹,

Jordan

2001

J of Applied Toxicology

111

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Aqueous solutions of > or =5% glutaraldehyde (GA) are of moderate acute peroral toxicity and those of < or =2% are of slight toxicity. By single sustained skin contact, aqueous GA solutions of > or =45% are of moderate acute percutaneous toxicity, those of 25% are of slight toxicity and those of or =5%. Primary skin irritation depends on the duration and contact site, occlusion and solvent. By sustained contact, the threshold for skin irritation is 1%, above which erythema and edema are dose related. With 45% and higher, skin corrosion may occur. There is a low incidence of skin sensitizing reactions, with an eliciting threshold of 0.5% aqueous GA. However, GA is neither phototoxic nor photosensitizing. Subchronic repeated exposure studies by the peroral route show only renal physiological compensatory effects, secondary to reduced water consumption. Repeated skin contact shows only minor skin irritant effects without systemic toxicity. By subchronic vapor exposure, effects are limited to the nasal mucosa at 1.0 ppm, with a no-effect concentration generally at 0.1 ppm. There is no evidence for systemic target organ or tissue toxicity by subchronic repeated exposure by any route. A chronic drinking water study showed an apparent increase, in females only, of large granular cell lymphocytic leukemia but this was not dosage related. This is most likely the result of a modifying effect on the factor(s) responsible for the expression of this commonly occurring rat neoplasm. A chronic (2-year) inhalation toxicity/oncogenicity study showed inflammatory changes in the anterior nasal cavity but no neoplasms or systemic toxicity. In vitro genotoxicity studies--bacterial mutagenicity, forward gene mutation (HGPRT and TK loci), sister chromatid exchange, chromosome aberration, UDS and DNA repair tests--have given variable results, ranging from no effect through to weak positive. In vivo genotoxicity studies--micronucleus, chromosome aberration, dominant lethal and Drosophila tests--generally have shown no activity but one mouse intraperitoneal study showed bone marrow cell chromosome aberrations. Developmental toxicity studies show GA not to be teratogenic, and a two-generation study showed no adverse reproductive effects. Percutaneous pharmacokinetic studies showed low skin penetration, with lowest values measured in vitro in rats and human skin. Overexposure of humans produces typical sensory irritant effects on the eye, skin and respiratory tract. Some reports have described an asthmatic-like reaction by overexposure to GA vapor. In most cases this resembles reactive airways dysfunction s...

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Treatment of superficial onychomycosis with topically applied glutaraldehyde. A preliminary study

Cited by 11 publications

References 0 publications

Onychomycosis: diagnosis and topical therapy

Onychomycosis: diagnosis and topical therapy

Fungal (Onychomycosis) and Other Infections Involving the Nail Apparatus

Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures

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