Treatment of Superficial Basal Cell Carcinoma and Squamous Cell Carcinoma In Situ With a High-Energy Pulsed Carbon Dioxide Laser

Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser

“…The safety margin for laser treatment around tumors, which is often limited on the face, is the same as after surgery [4,5] as well as in case of treatment of skin carcinoma by CO 2 laser [13,14]. After the rejection of necrotic masses the positive wound margin on histological examination is observed only in some patients with BCC (0.3%) that confirms safety of margins.…”

“…It is worthy to stress that radiation Nd laser as well as other types of lasers [11][12][13][14] does not cause resistance of tumor cells to this therapeutic modality and therefore it may be effectively used for successive sessions in case of recurrences of BCC after initial laser application and also limited BCC recurrences that appeared after other methods of treatment [22,23].…”

“…The use of above mentioned methods for the treatment of facial carcinoma results in tumor recurrence in 1.6-9.5% patients [3][4][5][6][7][8][9][10]. The progress in treatment of skin carcinoma has been achieved after laser radiation was introduced into practice [11][12][13][14][15][16][17][18][19][20]. Previously we have shown that treatment of facial skin carcinoma by high-energy Nd laser radiation, resulted in deep destruction of tumors [21] and low recurrence rate [22,23].…”

Basal Cell Carcinoma. Treatment with Carbon Dioxide Laser Vaporization

“…In With ablative lasers as carbon dioxide laser (Adams and Price 1979, Wheeland et al 1987, Fairhurst et al 1992, Grobbelaar et al 1997, Krunic et al 1998, Humpreys et al 1998, Horlock et al 2000, Nouri et al 2002, Campolmi et al 2002, Robinson et al 2003 and erbium:YAG laser (Smuckler et al 2008), the angiogenic component being a guide to the surgeon that indicates the elimination of the tumour, the lesion can be vaporized as deep as possible with the increase of the passes number. The ability to vaporize of carbon dioxide laser is higher than erbium:YAG laser and the majority of studies concerning the treatment of BCC with ablative lasers was performed with CO2 laser.…”

“…Several treatment options for basal cell carcinoma have been described including surgical excision (Walker et al 2006), curettage (Barlow et al 2006) and cautery (Spiller et al 1984), cryotherapy (Mallon et al 1996, Kokoszka 2003, radiotherapy (AlOthman 2001), photodynamic therapy (Star et al 2006, Chapas et al 2006, Brathen et al 2007, micrographic surgery (Bieley et al 1992, Rowe et al 1989), ablative laser (Goldman and Wilson 1964, MacGuff 1966, Goldman et al 1968, Adams and Price 1979, Wheeland et al 1987, Fairhurst et al 1992, Grobbelaar et al 1997, Krunic et al 1998, Humpreys et al 1998, Horlock et al 2000, Nouri et al 2002, Campolmi et al 2002, Robinson et al 2003, and Smuckler et al 2008, other laser systems (El-Tonsy et al 2004, Moskalik et al 2009, Allison et al 2003, Campolmi et al 2008, Shah et al 2009, Konnikov et al 2011, Ibrahimi et al 2011, topical treatment with 5-fluorouracil and immunomodulators, such as imiquimod (Kagy andAmonette 2000, Schulze et al 2005) and intralesional agents as interferon (Greenway et al 1986).…”