Treatment of pustulosis palmaris et plantaris with oral doses of colchicine

Abstract

The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.

A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients

“…The efficacy of colchicine in PPP has been known for approximately 30 years, 34–36 and it is almost always preferred in the first‐line therapy for PPP in our polyclinic. While two randomized controlled trials have produced conflicting results about the efficacy, 35,37 60% of the colchicine users in the current study obtained marked improvement suggesting that colchicine should be evaluated among the first line therapies of PPP with the advantages of low side‐effect profile and cost‐effectiveness.…”

Successful colchicine administration in facial granulomas caused by cosmetic implants: Report of a case

“…In addition, it can be an alternative in several skin conditions including leucocytoclastic vasculitis, palmoplantar pustolosis, Behçet's syndrome and urticarial vasculitis (8)(9)(10)(11)(12)(13) while the list remains still open in the literature. This drug decreases phagocytosis and neutrophil chemotaxis (14).…”

Neutrophil Chemotaxis in Patients with Pustulotic Arthro-Osteitis

“…Colchicine inhibits the PMN chemotaxis [36], and suppresses inflammatory reac tions [37], It has in some studies been found of benefit in patients with PV [38], general pustular psoriasis [39], and PPP [40], although the effect on PPP in one controlled study was dubious [41]. Colchicine seemed to benefit 2 of the present patients with PPP and 6 patients without PPP, and their PMN chemotaxis became normal during the ther apy, consistent with a possible pathogenetic significance of the PMNs.…”