Treatment of Pustular Psoriasis and Pustular Bacterid With Quinacrine (Atabrine)

Cormia, Frank E.

doi:10.1001/archderm.1953.01540090099016

Cited by 18 publications

(2 citation statements)

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“…In so far as reports of successful treatment are concerned [5,12,17], they involved atypical forms, for example pustular p. or p. com bined with lupus erythematosus [5], or antimalarials were adminis tered for only 7 to 10 days [17]. It is noteworthy that in cases in which improvement is reported following antimalarials, atabrine was always administered.…”

Section: Discussionmentioning

confidence: 99%

Photosensitive Psoriasis

Bielický¹,

Kvíčalová²

1964

Dermatology

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Section: Discussionmentioning

confidence: 99%

Photosensitive Psoriasis

Bielický¹,

Kvíčalová²

1964

Dermatology

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“…A total of 5 drug molecules associated with disease were screened, among which mepacrine (quinacrine) and camptothecin were negatively related to disease. Mepacrine was an antimalaria drug known to everyone, and moreover, it has a certain therapeutic effect on psoriasis [28] . As an antifungal drug, camptothecin could accelerate the formation of the epidermal granular layer and horny cell keratosis, and therefore, it was used for the treatment of psoriasis, whose therapeutic effects could at least partly be explained by its multiple effects on DNA as a topoisomerase inhibitor [29] .…”

Section: Discussionmentioning

confidence: 99%

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Mei¹,

Mei²

2017

Dermatology

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Aim: Psoriasis is an inflammatory skin disease, and approximately one quarter of individuals with psoriasis develop painful and debilitating arthritis. As a complex and polygenetic hereditary disease, it is significant to investigate skin lesion-associated genes of psoriasis. Method: In the present study, a total of 3,047 differentially expressed genes between lesional and nonlesional skin of psoriasis patients were screened based on 4 data sets in GEO DataSets. In the following, network module analyses were performed. Result: After calculating the correlation coefficients between eigenvalues of each module and disease status (psoriatic lesion and nonlesion), it was observed that the genes in black and green modules showed a significant correlation in each data set. Consequently, 58 significant characteristic genes of black modules and 74 of green modules were chosen for further analysis. The interaction network of the candidate feature genes was constructed based on the BioGRID, HPRD, and BIND databases, which contained 310 nodes. The mutual relationships of 70 genes, including 28 genes in the black module and 42 genes in the green module, were summarized, and 5 drug molecules related to these 70 factors were detected. Mepacrine and camptothecin were indicated as 2 drugs negatively related to psoriasis. Conclusion: The results suggested a pathogenesis mechanism of psoriasis and indicated novel therapeutic targets for psoriasis.

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Psoriasis, Ultraviolet Light, and Chloroquine

O'Quinn¹

1964

Arch Dermatol

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Treatment of Pustular Psoriasis and Pustular Bacterid With Quinacrine (Atabrine)

Cited by 18 publications

References 0 publications

Photosensitive Psoriasis

Photosensitive Psoriasis

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Psoriasis, Ultraviolet Light, and Chloroquine

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