Treatment of pulmonary neuroendocrine tumours: State of the art and future developments

Gridelli, Cesare; Rossi, Antonio; Airoma, Giuseppe; Bianco, Roberto; Costanzo, Raffaele; Daniele, Bruno; Chiara, Giovanni De; Grimaldi, Giuseppe; Irtelli, Luciana; Maione, Paolo; Morabito, Alessandro; Piantedosi, Franco Vito; Riccardi, Ferdinando

doi:10.1016/j.ctrv.2012.06.012

Cited by 65 publications

(61 citation statements)

References 79 publications

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“…Findings such as flushing, wheezing, and diarrhea can be seen in cases with NED 13 ; however, none of these symptoms were present in the NED (+) group of patients in this study.…”

Section: Discussioncontrasting

confidence: 77%

“…In addition, since LCNECs generally have a peripheral localization, findings of post-obstruction are rare. 13,15,20 Endobronchial localization was detected in 16 (21%) patients with post-obstruction atelectasis in only six (8%) patients in this study. Four of these patients (5%) were in the NED (+) group.…”

Section: Discussionmentioning

confidence: 48%

“…12 In addition, according to the Guidelines of the National Comprehensive Cancer Network, the treatment of these tumors was suggested to be similar to non-small cell lung cancers. 13 Many studies suggest a better prognosis be obtained with complete resection and systematic nodal dissection. 14,15,16 The efficacy of cisplatin-based chemotherapy in patients with LCNEC and small cell carcinomas were found to be similar to the reported objective response of 50%.…”

Section: Discussionmentioning

confidence: 99%

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Factors Effecting Long-term Survival in Operated Large Cell Carcinoma of the Lung.

Gürsoy¹

2015

UHOD

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The aim of this study was to evaluate of the results of the treatment of patients who underwent surgery due to large cell lung carcinoma and to analyze the variables affecting the survival outcomes. Pulmonary resections were performed on 1221 patients with pathological stages I, II, III non-small cell lung cancer between January 2003 and January 2013. A total of 85 patients (7%) who were histologically diagnosed with large cell lung carcinoma and 10 patients were excluded from the study because of operative mortality, incomplete resection, and follow-up. The records of 75 patients undergoing complete resection were evaluated in terms of demographics, survival rates, and variables affecting the survival. Seventy-one (94.7%) male and four (5.3%) female patients with a mean age of 58.1±9.8 years (range: 38 to 76 years) were included in the study. Neoadjuvant treatment was administered to four (5.3%) patients. Lobectomy was performed on 53 (70.7%) patients and 28 (37.3%) had neuroendocrine differentiation (NED) in their tumors. Median and five-year survival rates were 80.8 months and 51.1%, respectively in a mean follow-up period of 34.9±27.7 months (range: 2.4 to 91.6 months). Five-year survival rates in the groups with and without neuroendocrine differentiation were 37.8% and 57.9%, respectively, with no statistically significant difference between the groups (p=0.53). The absence of lymph node metastasis and adjuvant treatment had positive effects on survival in patients with large cell lung carcinoma who underwent resection. Although not statistically significant, neuroendocrine differentiation led to a lower survival rates. Nöroendokrin diferansiasyon saptanan ve saptanmayanlarda 5 yıllık sağkalım oranları sırası ile %37.8 ve %57.9 idi ve arada istatistiksel olarak anlamlı bir fark saptanmadı (p=0.53). Bu çalışmada rezeke edilen büyük hücreli akciğer karsinomlu hastalarda, lenf bezi metastazının olmaması ve adjuvan tedavi uygulanımının sağkalıma etkisinin daha iyi olduğu saptandı. İstatistiksel olarak anlamlı olmasa da nöroendokrin diferansiasyon, daha kötü bir sağkalım oranı göstermiştir. Ancak lokal yayılım izlenmeyen ve adjuvan tedavi uygulanan hastalarda sağkalım sonuçlarının daha iyi olması beklenebilir.Anahtar Kelimeler: Büyük hücreli akciğer karsinomu, Nöroendokrin diferansiasyon, Cerrahi, Sağkalım 255UHOD

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“…Findings such as flushing, wheezing, and diarrhea can be seen in cases with NED 13 ; however, none of these symptoms were present in the NED (+) group of patients in this study.…”

Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

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Factors Effecting Long-term Survival in Operated Large Cell Carcinoma of the Lung.

Gürsoy¹

2015

UHOD

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show abstract

“…However, an increasing body of knowledge is accumulating in lung NET about biomarkers with predictive value, which could modify the therapy of these tumors in near future. This holds true especially for TC and AC where treatment, when non directly surgical (as mainly happens), relies on multimodality approaches or non-conventional drugs, whilst LCNEC and SCLC are generally cured by exclusive chemo-radiotherapy 87,88 .…”

Section: Predicting In Netmentioning

confidence: 99%

What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?

Pelosi

Fabbri

Cossa

et al. 2015

Seminars in Diagnostic Pathology

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“…According to the grades of biological aggressiveness (G1-G3) and differentiated degrees (well-differentiated or poorly-differentiated), both TC (G1) and AC (G2) belong to well-differentiated neoplasms, while LCNEC and SCLC (G3) to poorly-differentiated ones (Gridelli et al, 2013). Some scholars reported that the 5-year survival rate for TC was more than 87% (Thomas et al, 2001;Travis et al, 1998).…”

Section: Analysis On the Characteristics And Prognosis Of Pulmonarymentioning

confidence: 99%

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Hu²,

Sun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Treatment of pulmonary neuroendocrine tumours: State of the art and future developments

Cited by 65 publications

References 79 publications

Factors Effecting Long-term Survival in Operated Large Cell Carcinoma of the Lung.

Factors Effecting Long-term Survival in Operated Large Cell Carcinoma of the Lung.

What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

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