Treatment of Psoriasis With Large Doses of Vitamin B12 1,100 Micrograms Per Cubic Centimeter

Ruedemann, Rudolph

doi:10.1001/archderm.1954.01540180088013

Cited by 14 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All patients referred an improvement in clinical symptoms and decrease in itching; these data have been measured through pVAS. Our results confirm the already demonstrated positive effect of vitamin B 12 , 12 , 13 demonstrating furthermore the reduction in extension and severity of psoriasis and atopic dermatitis with the B 12 topical treatment. In addition to the immunomodulatory effect, vitamin B 12 ointment reestablish the needed level on psoriatic skin, thus, patients affected from psoriatic are frequently affected by vitamin B 12 deficiency.…”

Section: Discussionsupporting

confidence: 91%

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Duca

Farnetani

Carvalho

et al. 2017

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disease affecting 2%–3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks. This study was conducted as a randomized, controlled, single-blind, intra-patient left- to right-side trial comparing the efficacy and safety of vitamin B12-containing ointment (M-treatment) with a glycerol-petrolatum-based emollient cream (C-treatment). The Psoriasis Area Severity Index (PASI) was determined at baseline (T0), at time points T2 (14 days), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks) and 4 weeks after the end of the wash-out period (F1). In total, 24 patients with plaque psoriasis were randomized to receive left- or right-side treatment with B12 ointment. From time point T2 to time point F1, there was a statistically significant difference in PASI reduction between M-treatment side and C-treatment side. At time point T 12, the difference between the mean reductions from baseline PASI scores by 5.92 ± 2.49 (87, 6%) in the M-treatment side versus 1.08 ± 1.02 (23, 1%) C-treatment side was statistically highly significant (PWex < 0.001). On the contemporary panorama in the treatment of psoriasis, we conclude that vitamin B12 ointment will represent a new concrete therapy option and should be considered in the update of therapeutic algorithm for the treatment of psoriasis

show abstract

Section: Discussionsupporting

confidence: 91%

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Duca

Farnetani

Carvalho

et al. 2017

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…Although a small number of pediatric patients are included in some studies, the data are insufficient to make recommendations for pediatric psoriasis. Study characteristics and outcome data are summarized in Table 1 and Table 2 . Quality assessment results for observational studies are included in Table 1; results for interventional studies are reported in the eTable in the Supplement.…”

Section: Results Of the Systematic Review And Npf Recommendationsmentioning

confidence: 99%

Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation

et al. 2018

View full text Add to dashboard Cite

IMPORTANCEPsoriasis is a chronic, inflammatory skin disease and has significant associated morbidity and effect on quality of life. It is important to determine whether dietary interventions help reduce disease severity in patients with psoriatic diseases. OBJECTIVE To make evidence-based dietary recommendations for adults with psoriasis and/or psoriatic arthritis from the Medical Board of the National Psoriasis Foundation.EVIDENCE REVIEW We used literature from prior systematic reviews as well as additional primary literature from the MEDLINE database from January 1, 2014, to August 31, 2017, that evaluated the impact of diet on psoriasis. We included observational and interventional studies of patients with psoriasis or psoriatic arthritis. The quality of included studies was assessed using the Newcastle-Ottawa scale for observational studies and the Cochrane Risk of Bias Tool for interventional studies. We made evidence-based dietary recommendations, which were voted on by the National Psoriasis Foundation Medical Board.FINDINGS We identified 55 studies meeting the inclusion criteria for this review. These studies represent 77 557 unique participants of which 4534 have psoriasis. Based on the literature, we strongly recommend dietary weight reduction with a hypocaloric diet in overweight and obese patients with psoriasis. We weakly recommend a gluten-free diet only in patients who test positive for serologic markers of gluten sensitivity. Based on low-quality data, select foods, nutrients, and dietary patterns may affect psoriasis. For patients with psoriatic arthritis, we weakly recommend vitamin D supplementation and dietary weight reduction with a hypocaloric diet in overweight and obese patients. Dietary interventions should always be used in conjunction with standard medical therapies for psoriasis and psoriatic arthritis.CONCLUSIONS AND RELEVANCE Adults with psoriasis and/or psoriatic arthritis can supplement their standard medical therapies with dietary interventions to reduce disease severity. These dietary recommendations from the National Psoriasis Foundation Medical Board will help guide clinicians regarding the utility of dietary interventions in adults with psoriatic diseases.

show abstract

“…However, few studies have investigated the role of intramuscular administration of vitamin B12 in the treatment of psoriasis. Ruedemann found favorable results with the administration of 1,000 g per cubic centimeter of vitamin B12 intramuscularly for 10 consecutive days, followed by a maintenance dose 33 . Thirty-two percent (11/34) of patients cleared their psoriasis lesions and 29% (10/34) reached PASI 75.…”

Section: Resultsmentioning

confidence: 99%

Diet and psoriasis, part III: Role of nutritional supplements

Millsop

Bhatia

Debbaneh

et al. 2014

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Psoriasis patients are increasingly turning to the use of alternative and complementary medicine to manage their psoriasis. Patients often inquire about what dietary supplements may be beneficial, including the use of oral vitamin D, vitamin B12, selenium, and omega-3 fatty acids in fish oils. In this review we examine the extent to which each of these common nutritional interventions has been studied for the treatment of psoriasis. We weighed evidence from both controlled and uncontrolled prospective trials. The evidence of benefit was highest for fish oils. For other supplements, there is need for additional large, randomized clinical trials to establish evidence of efficacy.

show abstract

Treatment of Psoriasis With Large Doses of Vitamin B12 1,100 Micrograms Per Cubic Centimeter

Cited by 14 publications

References 0 publications

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation

Diet and psoriasis, part III: Role of nutritional supplements

Contact Info

Product

Resources

About

Treatment of Psoriasis With Large Doses of Vitamin B12 1,100 Micrograms Per Cubic Centimeter

Cited by 14 publications

References 0 publications

Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation

Diet and psoriasis, part III: Role of nutritional supplements

Contact Info

Product

Resources

About

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

Superiority of a vitamin B₁₂-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis