2013
DOI: 10.1590/abd1806-4841.20131800
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Abstract: BACKGROUND Pityriasis versicolor is a fungal infection caused by Malassezia spp. that has frequent relapses. OBJECTIVES The main objective of this research was to perform phase I and II clinical studies, using formulations containing essential oil of Cymbopogon citratus in patients with pityriasis versicolor. METHODS Phase I study included twenty volunteers to ascertain the safety of the formulations. In phase II, 47 volunteers randomly received essential oil formulations at 1.25 μL/mL concentration, for for… Show more

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Cited by 19 publications
(11 citation statements)
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References 18 publications
(13 reference statements)
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“… Hunsukusɛ / Hunsikonu (F) Compositae Pe Dec; Pounding; Grilling Oral + Topic 22.94 20.16 100 0 36 YH 362 / HNB Cymbopogon citratus (DC.) Stapf Tcha; Ca / Ti (man) (f) Poaceae Le Dec Oral 2.75 2.42 100 0 [ 56 ] 37 YH 363 / HNB Daniellia oliveri (Rolfe) Hutch. & Dalziel Zaxaya (f) Leguminosae Tf Dec Oral + Topic 1.83 1.61 100 0 R 38 YH 310 / HNB Desmodium velutinum (Willd.)…”
Section: Resultsmentioning
confidence: 99%
“…Due to the possible irritation potential of these EOs on skin and mucous membranes, it is commonly recommended by practitioners that EOs are used only in diluted forms for external application (Carmo et al . ).…”
Section: Discussionmentioning
confidence: 97%
“…The threshold concentration was determined in vitro using a modified hen's egg test, chorioallontois membrane assay (Wilson and Steck 2000), which should be applied in further investigations. Due to the possible irritation potential of these EOs on skin and mucous membranes, it is commonly recommended by practitioners that EOs are used only in diluted forms for external application (Carmo et al 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies continue to demonstrate the antifungal activity of essential oils [80,81,82,83] and consequently increase the possibility of applying these products to the prevention and/or treatment of fungal infectious diseases. The biological activity of essential oils has been shown to be dependent on their chemical compositions, which include citral, pinene, cineole, caryophyllene, elemene, furanodiene, limonene eugenol, eucalyptol and carvacrol.…”
Section: Natural Derivatives With Antifungal Propertiesmentioning
confidence: 99%
“…One example is the research conducted by Carmo et al . [81], which tested the essential oil of Cymbopogon citratus in shampoo and cream formulations to treat pityriasis versicolor. They proved that the formulations, which did not cause significant adverse reactions in healthy volunteers, were safe, and after treatment, a 60% mycological cure rate was observed for the group treated with this essential oil.…”
Section: Natural Derivatives With Antifungal Propertiesmentioning
confidence: 99%