Treatment of Pemphigus Vulgaris and Bullous Pemphigoid With Mycophenolate Mofetil Monotherapy

Efficacy and safety of long‐term mycophenolate sodium therapy in pemphigus vulgaris

“…1 Mycophenolic acid was first used in renal transplant rejection and then found to be effective in the treatment of pemphigus and pemphigoid. 4,5 Optimal regimen in immunobullous diseases should induce remission rapidly, maintain effectiveness for long time, be well tolerated and have minimal iatrogenic adverse events. We have treated six patients who were refractory, and five of them have developed side-effects with prior therapies.…”

Mycophenolate mofetil in dermatology

“…[24][25][26][27][28][29][30][31][32][33][34][35][36][37] Diseases include pemphigus vulgaris, bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, pemphigus foliaceus, and paraneoplastic pemphigus.…”

Management of autoimmune bullous diseases: Pharmacology and therapeutics

“…Recently, 2 case reports confirmed the effective use of mycophenolate mofetil as monotherapy for PV. 37,38 More recently, an open trial of mycophenolate mofetil in the treatment of resistant PV was reported. Ten patients with severe, resistant PV were given 2 g daily of the agent with systemic glucocorticoids.…”

“…97 Mycophenolate is effective both as a sole agent and in combination with glucocorticoids. 38,81,95,98 Azathioprine is commonly used in a dose of 2 to 3 mg/kg/d. 99 The dose may be adjusted on the basis of clinical response, side effects, and thiopurine methyltransferase level.…”